Biology of tumors and head and neck cancer chemotherapy.


Journal Article

The management of advanced squamous cell carcinomas of the head and neck has shown disappointing results with surgery and radiation alone. Chemotherapy offers a third method of managing these patients. A background of basic tumor biology and cell cycle kinetics is essential in designing an effective head and neck chemotherapeutic protocol. The principles of the cell cycle, stem cell regulation, and doubling times are discussed. The kinetic classification of chemotherapeutic agents and experimental hypotheses of clinical relevance are reviewed.

Full Text

Cited Authors

  • Gussack, GS; Brantley, BA; Farmer, JC

Published Date

  • September 1, 1984

Published In

Volume / Issue

  • 94 / 9

Start / End Page

  • 1181 - 1187

PubMed ID

  • 6472015

Pubmed Central ID

  • 6472015

International Standard Serial Number (ISSN)

  • 0023-852X

Digital Object Identifier (DOI)

  • 10.1288/00005537-198409000-00010


  • eng

Conference Location

  • United States