Effect of continuous complement inhibition using soluble complement receptor type 1 on survival of pig-to-primate cardiac xenografts.

Journal Article

A single bolus of soluble complement (C) receptor type 1 (sCR1, TP-10) has been shown to delay hyperacute rejection (HAR) of porcine cardiac xenografts (Xgs) by primate recipients. In these recipients, C activity slowly returned and C deposition was noted in the Xgs at rejection. To evaluate the effect of sustained C inhibition using sCR1 on HAR, two additional cynomolgus monkeys received porcine cardiac Xgs and a continuous infusion of sCR1. In the first recipient, Xgs survival was 5 days (120+ hr), whereas in the second, Xg survival was 7 days (168+ hr). Serial biopsies of the Xgs were remarkable for an increasing cellular infiltrate composed predominantly of neutrophils and macrophages, and the development of edema, hemorrhage, and myocyte necrosis. These findings suggest that once C-mediated HAR has been inhibited, infiltration of the Xg by these cells may lead to accelerated acute rejection, which is an additional barrier to successful longer term Xg survival.

Full Text

Duke Authors

Cited Authors

  • Pruitt, SK; Bollinger, RR; Collins, BH; Marsh, HC; Levin, JL; Rudolph, AR; Baldwin, WM; Sanfilippo, F

Published Date

  • March 27, 1997

Published In

Volume / Issue

  • 63 / 6

Start / End Page

  • 900 - 902

PubMed ID

  • 9089232

International Standard Serial Number (ISSN)

  • 0041-1337

Language

  • eng

Conference Location

  • United States