Prospects for cellular immunotherapy for metastatic melanoma.

Journal Article (Journal Article;Review)

Systemic therapy for metastatic malignant melanoma has been disappointing. The search for alternate therapeutic methods includes investigation of the interaction between melanoma and the human immune system. A cellular immune response to melanoma has been documented in vitro and in vivo. In most patients with disseminated disease, however, immune T cells fail to eradicate the tumor. While this phenomenon is poorly understood, the occasional occurrence of spontaneous regression provides some indication that the immune response may, in fact, be capable of eradicating established tumor in vivo. Current efforts to augment and to direct the immune response to melanoma include investigation of specific and nonspecific adoptive immunotherapy. Specific therapy includes the generation of tumor-activated specific killer cells from peripheral blood, draining nodes, or metastatic tumor deposits. An increasing understanding of antigen recognition and improved methodology for T-cell culture are contributing toward the application of cellular immunotherapy to patients with melanoma.

Full Text

Duke Authors

Cited Authors

  • Slingluff, CL; Seigler, HF

Published Date

  • January 1992

Published In

Volume / Issue

  • 28 / 1

Start / End Page

  • 110 - 113

PubMed ID

  • 1642398

International Standard Serial Number (ISSN)

  • 0148-7043

Digital Object Identifier (DOI)

  • 10.1097/00000637-199201000-00028


  • eng

Conference Location

  • United States