Prognosis for recurrent stage I malignant melanoma.


Journal Article

The outcome of patients with stage I malignant melanoma has been well assessed in terms of prognostic factors and their effect on survival; however, little is known of the recurrence patterns of cutaneous melanoma or the survival of these patients subsequent to recurrence. A retrospective, computer-aided chart review identified 4185 patients with melanoma who had stage I disease clinically. During a follow-up period of one to 14 years, 35.9% suffered a recurrence. Melanoma of the trunk (37.8%) and head and neck area (46.1%) had an increased incidence of recurrent metastases compared with melanoma of the extremities (29.8%). Local regional metastases accounted for 62.5%, 77.3%, and 85.6% of the recurrences in the head and neck, trunk, and extremity primary sites, respectively, with 65% of the relapses occurring within the first three years. Actuarial five-year survival rates of patients who had recurrent disease were significantly decreased compared with those of patients who had no evidence of metastases during their clinical course. A multivariate analysis was performed to estimate the survival of patients after recurrence. One may use this mathematical model to predict the outcome of individual patients after recurrence and provide a more rationally based prognosis for them and their families.

Full Text

Duke Authors

Cited Authors

  • Reintgen, DS; Vollmer, R; Tso, CY; Seigler, HF

Published Date

  • November 1987

Published In

Volume / Issue

  • 122 / 11

Start / End Page

  • 1338 - 1342

PubMed ID

  • 3675198

Pubmed Central ID

  • 3675198

International Standard Serial Number (ISSN)

  • 0004-0010


  • eng

Conference Location

  • United States