Skip to main content

Malignant melanoma arising during pregnancy. A study of 100 patients.

Publication ,  Journal Article
Slingluff, CL; Reintgen, DS; Vollmer, RT; Seigler, HF
Published in: Ann Surg
May 1990

Melanoma is often diagnosed in young adults, a significant proportion of whom are women of child-bearing age. The prognosis of women diagnosed with melanoma during a pregnancy continues to be debated. One hundred patients, ages 19 to 40 years, have been identified who were pregnant at the time of diagnosis of their melanoma. All were treated with local excision. Sixteen per cent underwent elective lymph node dissections. Immunotherapy was administered to 83% of patients. Mean follow-up was 6.8 years from the date of diagnosis. The patients were compared to an age-matched group of 86 women who were not pregnant at the time of diagnosis. Overall mortality during the follow-up period was 25% in the pregnant group and 23% in the control group. Among the pregnant group, there was an increased incidence of lymph node metastases during the follow-up period (39% versus 26%, p = 0.053). Among stage I patients, there was a significantly shorter DFI for the pregnant group (p = 0.039), with 50% of pregnant patients and 67% of control patients free of disease at 10 years. Similarly, among stage 1 patients, the time to development of lymph node metastases was shorter in the pregnant group (p = 0.021). Multivariate analysis demonstrated that pregnancy at diagnosis was significantly associated with the development of metastatic disease (p = 0.008), when controlling for tumor site, thickness, and Clark level. Patients who developed melanoma during pregnancy did not, however, have a significant decrease in survival.

Duke Scholars

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

May 1990

Volume

211

Issue

5

Start / End Page

552 / 557

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Skin Neoplasms
  • Prognosis
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Neoplasm Recurrence, Local
  • Neoplasm Metastasis
  • Melanoma
  • Lymphatic Metastasis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Slingluff, C. L., Reintgen, D. S., Vollmer, R. T., & Seigler, H. F. (1990). Malignant melanoma arising during pregnancy. A study of 100 patients. Ann Surg, 211(5), 552–557. https://doi.org/10.1097/00000658-199005000-00005
Slingluff, C. L., D. S. Reintgen, R. T. Vollmer, and H. F. Seigler. “Malignant melanoma arising during pregnancy. A study of 100 patients.Ann Surg 211, no. 5 (May 1990): 552–57. https://doi.org/10.1097/00000658-199005000-00005.
Slingluff CL, Reintgen DS, Vollmer RT, Seigler HF. Malignant melanoma arising during pregnancy. A study of 100 patients. Ann Surg. 1990 May;211(5):552–7.
Slingluff, C. L., et al. “Malignant melanoma arising during pregnancy. A study of 100 patients.Ann Surg, vol. 211, no. 5, May 1990, pp. 552–57. Pubmed, doi:10.1097/00000658-199005000-00005.
Slingluff CL, Reintgen DS, Vollmer RT, Seigler HF. Malignant melanoma arising during pregnancy. A study of 100 patients. Ann Surg. 1990 May;211(5):552–557.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

May 1990

Volume

211

Issue

5

Start / End Page

552 / 557

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Skin Neoplasms
  • Prognosis
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Neoplasm Recurrence, Local
  • Neoplasm Metastasis
  • Melanoma
  • Lymphatic Metastasis