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Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines.

Publication ,  Journal Article
Darrow, TL; Abdel-Wahab, Z; Seigler, HF
Published in: Cancer Control
October 1995

The incidence of melanoma in the United States is increasing at a faster rate than that of any other cancer. The prognosis for metastatic disease is poor, and more effective treatments for disseminated disease are needed. Since melanoma is one of the more immunogenic tumors, strategies have focussed on immune recognition. In vitro studies suggest that potent tumor-specific cytotoxic T cells can be induced against human melanoma. Melanoma specific T-cell activation depends on appropriate presentation to the immune system of recently defined melanoma-associated antigens presented in the context of self-HLA gene products. Full T-cell activation requires the co- stimulation by B7-CD28 interactions at the T-cell surface and the elaboration of immune cytokines to promote T-cell growth. Data from animal models of tumor-specific immunization with tumor cells engineered to express immune cytokines or the B7 co-stimulatory molecule suggest that gene therapy for human melanoma may be an effective means to treat disseminated disease.

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Published In

Cancer Control

DOI

EISSN

1526-2359

Publication Date

October 1995

Volume

2

Issue

5

Start / End Page

415 / 423

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Darrow, T. L., Abdel-Wahab, Z., & Seigler, H. F. (1995). Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines. Cancer Control, 2(5), 415–423. https://doi.org/10.1177/107327489500200505
Darrow, T. L., Z. Abdel-Wahab, and H. F. Seigler. “Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines.Cancer Control 2, no. 5 (October 1995): 415–23. https://doi.org/10.1177/107327489500200505.
Darrow TL, Abdel-Wahab Z, Seigler HF. Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines. Cancer Control. 1995 Oct;2(5):415–23.
Darrow, T. L., et al. “Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines.Cancer Control, vol. 2, no. 5, Oct. 1995, pp. 415–23. Pubmed, doi:10.1177/107327489500200505.
Darrow TL, Abdel-Wahab Z, Seigler HF. Immunotherapy of Human Melanoma With Gene-Modified Tumor Cell Vaccines. Cancer Control. 1995 Oct;2(5):415–423.

Published In

Cancer Control

DOI

EISSN

1526-2359

Publication Date

October 1995

Volume

2

Issue

5

Start / End Page

415 / 423

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis