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Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal.

Publication ,  Journal Article
Snyderman, R; Seigler, HF; Meadows, L
Published in: J Natl Cancer Inst
January 1977

The chemotactic responsiveness of peripheral blood monocytes was studied before and after immunotherapy was administered to 56 patients with melanoma. Abnormal chemotaxis was found in 36 patients (64%) prior to treatment; this abnormality correlated with severity of disease and prognosis. Immunotherapy with BCG and sensitized autologous lymphocytes and X-irradiated melanoma cells or surgical removal of the neoplasm both reduced the percentage of patients with abnormal chemotactic responses. The best prognosis was found for those patients who had normal chemotaxis prior to therapy. The data support the hypothesis that abnormalities of monocyte function might render the host less likely to destroy developing neoplasms and that malignant tumors themselves might affect monocyte function.

Duke Scholars

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

January 1977

Volume

58

Issue

1

Start / End Page

37 / 41

Location

United States

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Mycobacterium bovis
  • Monocytes
  • Middle Aged
  • Melanoma
  • Immunotherapy
  • Humans
  • Child
  • Chemotaxis, Leukocyte
 

Citation

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Snyderman, R., Seigler, H. F., & Meadows, L. (1977). Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst, 58(1), 37–41. https://doi.org/10.1093/jnci/58.1.37
Snyderman, R., H. F. Seigler, and L. Meadows. “Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal.J Natl Cancer Inst 58, no. 1 (January 1977): 37–41. https://doi.org/10.1093/jnci/58.1.37.
Snyderman R, Seigler HF, Meadows L. Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst. 1977 Jan;58(1):37–41.
Snyderman, R., et al. “Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal.J Natl Cancer Inst, vol. 58, no. 1, Jan. 1977, pp. 37–41. Pubmed, doi:10.1093/jnci/58.1.37.
Snyderman R, Seigler HF, Meadows L. Abnormalitieis of monocyte chemotaxis in patients with melanoma: effects of immunotherapy and tumor removal. J Natl Cancer Inst. 1977 Jan;58(1):37–41.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

January 1977

Volume

58

Issue

1

Start / End Page

37 / 41

Location

United States

Related Subject Headings

  • Prognosis
  • Oncology & Carcinogenesis
  • Mycobacterium bovis
  • Monocytes
  • Middle Aged
  • Melanoma
  • Immunotherapy
  • Humans
  • Child
  • Chemotaxis, Leukocyte