Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.

Journal Article (Journal Article;Review)

The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.

Full Text

Duke Authors

Cited Authors

  • Kypson, AP; Morphew, E; Jones, R; Gottfried, MR; Seigler, HF

Published Date

  • February 2003

Published In

Volume / Issue

  • 82 / 2

Start / End Page

  • 132 - 136

PubMed ID

  • 12561070

International Standard Serial Number (ISSN)

  • 0022-4790

Digital Object Identifier (DOI)

  • 10.1002/jso.10181


  • eng

Conference Location

  • United States