Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.
Journal Article (Journal Article;Review)
The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.
- Kypson, AP; Morphew, E; Jones, R; Gottfried, MR; Seigler, HF
- February 2003
Volume / Issue
- 82 / 2
Start / End Page
- 132 - 136
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States