Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism.
The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.
Kypson, AP; Morphew, E; Jones, R; Gottfried, MR; Seigler, HF
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