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Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle.

Publication ,  Journal Article
McCarty, KS; Sasso, R; Budwit, D; Georgiade, GS; Seigler, HF
Published in: Am J Pathol
June 1982

Differences in immunoglobulin localization (IgG, IgM, IgA) in benign versus malignant lesions of the human mammary gland have been previously demonstrated. The present investigation was undertaken to evaluate the influence of menstrual cycling on these immunoglobulins in the breast. Tissues were studied from 53 normal breasts. The patients were 16 to 51 years old, with a mean age of 35 +/- 9 years, and were documented as having regular menstrual cycling, lack of debilitating disease, and abstinence from use of hormones or from medications that might influence the pituitary-ovarian axis. Immunoglobulin localization in the tissue section was determined by direct immunofluorescence with antibodies specific for IgG, IgA, IgM, and IgA secretory component. The breast tissues were categorized into 5 histologically distinct menstrual cycle phases. No significant IgG localization was noted. IgA concentration was noted principally in the preovulatory phase of the cycle (P less than 0.03). IgM showed a similar variance, and IgA secretory component paralleled IgA localization. No correlation between IgA and IgM localization and plasma cells infiltration nor between plasma cell infiltration and menstrual cycle phase could be documented. These data suggest that menstrual cycling influences the human breast as part of the secretory immune system.

Duke Scholars

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

June 1982

Volume

107

Issue

3

Start / End Page

322 / 326

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Menstruation
  • Immunoglobulins
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin A, Secretory
  • Immunoglobulin A
  • Humans
  • Fluorescent Antibody Technique
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McCarty, K. S., Sasso, R., Budwit, D., Georgiade, G. S., & Seigler, H. F. (1982). Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle. Am J Pathol, 107(3), 322–326.
McCarty, K. S., R. Sasso, D. Budwit, G. S. Georgiade, and H. F. Seigler. “Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle.Am J Pathol 107, no. 3 (June 1982): 322–26.
McCarty KS, Sasso R, Budwit D, Georgiade GS, Seigler HF. Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle. Am J Pathol. 1982 Jun;107(3):322–6.
McCarty, K. S., et al. “Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle.Am J Pathol, vol. 107, no. 3, June 1982, pp. 322–26.
McCarty KS, Sasso R, Budwit D, Georgiade GS, Seigler HF. Immunoglobulin localization in the normal human mammary gland: variation with the menstrual cycle. Am J Pathol. 1982 Jun;107(3):322–326.
Journal cover image

Published In

Am J Pathol

ISSN

0002-9440

Publication Date

June 1982

Volume

107

Issue

3

Start / End Page

322 / 326

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Menstruation
  • Immunoglobulins
  • Immunoglobulin M
  • Immunoglobulin G
  • Immunoglobulin A, Secretory
  • Immunoglobulin A
  • Humans
  • Fluorescent Antibody Technique