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Immunological consequences of transplanting rat insulinomas.

Publication ,  Journal Article
Reintgen, D; Croker, B; Vervaert, C; Feldman, J; Seigler, HF
Published in: Transplantation
July 1980

We investigated the genetics of transplanting a NEDH rat insulinoma in various donor-recipient combinations. The insulinoma survived indefinitely when it was transplanted in the NEDH strain. Mean survival times of 8.6 +/- 1.2 and 3.3 +/- 1.0 days were recorded in allogeneic and xenogeneic combinations, respectively. No prolongation of mean survival time was found when the rat insulinoma was first passed through the athymic nude mouse and then transplanted as either an allograft or xenograft. The findings of the major histocompatibility antigen (Ag-B7) on the original insulinoma and the tumor that had been passed through the nude mouse demonstrates no demonstrable loss of transplantation antigens during passage.

Duke Scholars

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 1980

Volume

30

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Surgery
  • Rats, Inbred Strains
  • Rats
  • Pancreatic Neoplasms
  • Pancreas
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred Strains
  • Mice
  • Histocompatibility Antigens
 

Citation

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Reintgen, D., Croker, B., Vervaert, C., Feldman, J., & Seigler, H. F. (1980). Immunological consequences of transplanting rat insulinomas. Transplantation, 30(1), 16–22. https://doi.org/10.1097/00007890-198007000-00004
Reintgen, D., B. Croker, C. Vervaert, J. Feldman, and H. F. Seigler. “Immunological consequences of transplanting rat insulinomas.Transplantation 30, no. 1 (July 1980): 16–22. https://doi.org/10.1097/00007890-198007000-00004.
Reintgen D, Croker B, Vervaert C, Feldman J, Seigler HF. Immunological consequences of transplanting rat insulinomas. Transplantation. 1980 Jul;30(1):16–22.
Reintgen, D., et al. “Immunological consequences of transplanting rat insulinomas.Transplantation, vol. 30, no. 1, July 1980, pp. 16–22. Pubmed, doi:10.1097/00007890-198007000-00004.
Reintgen D, Croker B, Vervaert C, Feldman J, Seigler HF. Immunological consequences of transplanting rat insulinomas. Transplantation. 1980 Jul;30(1):16–22.

Published In

Transplantation

DOI

ISSN

0041-1337

Publication Date

July 1980

Volume

30

Issue

1

Start / End Page

16 / 22

Location

United States

Related Subject Headings

  • Surgery
  • Rats, Inbred Strains
  • Rats
  • Pancreatic Neoplasms
  • Pancreas
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice, Inbred Strains
  • Mice
  • Histocompatibility Antigens