Immunological consequences of transplanting rat insulinomas.
Journal Article
We investigated the genetics of transplanting a NEDH rat insulinoma in various donor-recipient combinations. The insulinoma survived indefinitely when it was transplanted in the NEDH strain. Mean survival times of 8.6 +/- 1.2 and 3.3 +/- 1.0 days were recorded in allogeneic and xenogeneic combinations, respectively. No prolongation of mean survival time was found when the rat insulinoma was first passed through the athymic nude mouse and then transplanted as either an allograft or xenograft. The findings of the major histocompatibility antigen (Ag-B7) on the original insulinoma and the tumor that had been passed through the nude mouse demonstrates no demonstrable loss of transplantation antigens during passage.
Full Text
Duke Authors
Cited Authors
- Reintgen, D; Croker, B; Vervaert, C; Feldman, J; Seigler, HF
Published Date
- July 1, 1980
Published In
Volume / Issue
- 30 / 1
Start / End Page
- 16 - 22
PubMed ID
- 6249003
Pubmed Central ID
- 6249003
International Standard Serial Number (ISSN)
- 0041-1337
Digital Object Identifier (DOI)
- 10.1097/00007890-198007000-00004
Language
- eng
Conference Location
- United States