The immunogenicity of human HL-A haplotypesas measured by skin graft survival times and mixed leukocyte reactions.

Journal Article (Journal Article)

The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1-12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.

Full Text

Duke Authors

Cited Authors

  • Seigler, HF; Ward, FE; Amos, DB; Phaup, MB; Stickel, DL

Published Date

  • March 1, 1971

Published In

Volume / Issue

  • 133 / 3

Start / End Page

  • 411 - 423

PubMed ID

  • 4939150

Pubmed Central ID

  • PMC2138954

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.133.3.411


  • eng

Conference Location

  • United States