Alimentary tract complications after renal transplantation.

Journal Article (Journal Article)

A computer analysis of post renal transplantation gastrointestinal problems was performed to identify important associated clinical factors. Thirty-seven per cent of all transplant recipients developed one or more significant problems. Hemorrhage, nondiverticular intestinal perforation, and esophagitis occurred most frequently in hospitalized patients. Pancreatitis, diverticulitis, and gastroduodenal perforation occurred characteristically in long-term survivors with well functioning allografts. Eleven of 32 HLA identical recipients treated with maintenance corticosteroids during stable kidney function developed gastrointestinal disease while only one of 13 HLA identical recipients not given maintenance steroids developed a problem, which strongly suggests a causal role for steroids in the development of late complications. The association of preexisting peptic ulcer and diverticular disease with hemorrhage and perforation supports previous recommendations that documented peptic ulcer disease or diverticulitis should be corrected surgically prior to transplantation.

Full Text

Duke Authors

Cited Authors

  • Meyers, WC; Harris, N; Stein, S; Brooks, M; Jones, RS; Thompson, WM; Stickel, DL; Seigler, HF

Published Date

  • October 1, 1979

Published In

Volume / Issue

  • 190 / 4

Start / End Page

  • 535 - 542

PubMed ID

  • 384945

Pubmed Central ID

  • PMC1344524

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-197910000-00013


  • eng

Conference Location

  • United States