Immunodiagnosis of melanoma using chimpanzee antihuman melanoma antiserum.

Journal Article (Journal Article)

Three cases of metastatic malignant lesions are presented. By conventional pathologic examination these lesions were diagnosed as undifferentiated carcinomas. They were studied using a chimpanzee antiserum specific for human melanoma-associated antigens. In each case, cells from the tumor were reactive with the anti-melanoma antiserum. The tumors were also studied using the DOPA test. All three tumors were positive in the DOPA test, suggesting the presence of tyrosinase within the tumor cells. The results suggest that serologic identification of melanoma may provide a rapid, inexpensive means for tumor diagnosis.

Full Text

Duke Authors

Cited Authors

  • Stuhlmiller, GM; Boylston, JA; Seigler, HF; Fetter, BF

Published Date

  • June 1977

Published In

Volume / Issue

  • 67 / 6

Start / End Page

  • 573 - 579

PubMed ID

  • 326027

International Standard Serial Number (ISSN)

  • 0002-9173

Digital Object Identifier (DOI)

  • 10.1093/ajcp/67.6.573


  • eng

Conference Location

  • England