Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.

Journal Article (Journal Article)

Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was found that by transplantation of a benign insulinoma, the glomerular deposition of material stained by the periodic acid-Schiff method, IgG, IgM, and C3 may be prevented. This effect was found only when transplantation of the insulin-producing tumor occurred within 2-4 weeks of the induction of diabetes. The data suggest that successful insulinoma engraftment can prevent the glomerular mesangial lesions from developing.

Full Text

Duke Authors

Cited Authors

  • Reintgen, DS; Croker, B; Verveart, C; Seigler, HF

Published Date

  • July 1983

Published In

Volume / Issue

  • 112 / 1

Start / End Page

  • 1 - 6

PubMed ID

  • 6305199

Pubmed Central ID

  • PMC1916325

International Standard Serial Number (ISSN)

  • 0002-9440


  • eng

Conference Location

  • United States