Comparison of monoamine oxidase in golden hamster islets and insulinoma.
Publication
, Journal Article
Feldman, JM; Castleberry, CA; Vervaert, C; Seigler, HF
Published in: Res Commun Chem Pathol Pharmacol
May 1983
We compared the properties of monoamine oxidase (MAO) in hamster islets and insulinomas. The tryptamine concentration at which the monoamine oxidase velocity was half maximal (Km) was higher in islets than insulinomas; the maximal velocity (Vmax) of monoamine oxidase was greater in islets than insulinomas. Both islet and insulinoma are more sensitive to inhibition by pargyline than clorgyline. After pargyline administration the monoamine oxidase activity of insulinoma returns faster than activity of islets. This may occur because both synthesis of new MAO in pre-existing cells and formation of new cells occurs in the insulinoma.
Duke Scholars
Published In
Res Commun Chem Pathol Pharmacol
ISSN
0034-5164
Publication Date
May 1983
Volume
40
Issue
2
Start / End Page
307 / 320
Location
United States
Related Subject Headings
- Tryptamines
- Pargyline
- Pancreatic Neoplasms
- Neoplasms, Experimental
- Monoamine Oxidase
- Mesocricetus
- Kinetics
- Islets of Langerhans
- Insulinoma
- Cricetinae
Citation
APA
Chicago
ICMJE
MLA
NLM
Feldman, J. M., Castleberry, C. A., Vervaert, C., & Seigler, H. F. (1983). Comparison of monoamine oxidase in golden hamster islets and insulinoma. Res Commun Chem Pathol Pharmacol, 40(2), 307–320.
Feldman, J. M., C. A. Castleberry, C. Vervaert, and H. F. Seigler. “Comparison of monoamine oxidase in golden hamster islets and insulinoma.” Res Commun Chem Pathol Pharmacol 40, no. 2 (May 1983): 307–20.
Feldman JM, Castleberry CA, Vervaert C, Seigler HF. Comparison of monoamine oxidase in golden hamster islets and insulinoma. Res Commun Chem Pathol Pharmacol. 1983 May;40(2):307–20.
Feldman, J. M., et al. “Comparison of monoamine oxidase in golden hamster islets and insulinoma.” Res Commun Chem Pathol Pharmacol, vol. 40, no. 2, May 1983, pp. 307–20.
Feldman JM, Castleberry CA, Vervaert C, Seigler HF. Comparison of monoamine oxidase in golden hamster islets and insulinoma. Res Commun Chem Pathol Pharmacol. 1983 May;40(2):307–320.
Published In
Res Commun Chem Pathol Pharmacol
ISSN
0034-5164
Publication Date
May 1983
Volume
40
Issue
2
Start / End Page
307 / 320
Location
United States
Related Subject Headings
- Tryptamines
- Pargyline
- Pancreatic Neoplasms
- Neoplasms, Experimental
- Monoamine Oxidase
- Mesocricetus
- Kinetics
- Islets of Langerhans
- Insulinoma
- Cricetinae