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Malignant melanoma and pregnancy.

Publication ,  Journal Article
Reintgen, DS; McCarty, KS; Vollmer, R; Cox, E; Seigler, HF
Published in: Cancer
March 15, 1985

Confusion exists concerning the influence of pregnancy on survival in patients with malignant melanoma. To evaluate this problem a retrospective computer-aided study was performed of women in the child-bearing years treated for Stage I cutaneous melanoma at the Duke University Comprehensive Cancer Center. Fifty-eight women were identified who had melanoma arise during pregnancy (Group 1) and 43 patients were noted who became pregnant within 5 years of diagnosis of their melanoma (Group 2). Appropriate control groups matched for the clinical variables of age, primary site, and stage of disease and the pathologic variables of Clark's Level, tumor thickness, ulceration, and histologic type were selected from the cohort of 2938 melanoma patients seen at Duke. Actuarial survivals for Group 1 and 2 patients did not differ from their respective controls, although the small number of deaths in each group resulted in wide confidence intervals. When actuarial disease-free intervals were plotted, there was a significant difference between women who had melanoma develop during pregnancy when compared to their controls (P = 0.04). In a multivariate regression analysis, after adjustment for the influence of the more significant prognostic factors for Stage 1 melanoma, including Clark's Level, ulceration and tumor thickness, the effect of pregnancy on disease-free interval became more apparent (P = 0.02). No difference in actuarial disease-free interval was noted in the melanoma patients who elected to become pregnant within 5 years of diagnosis (P = 0.31). A multivariate regression analysis confirmed this finding. These data indicate that although an intercurrent melanoma during pregnancy has a worse prognosis than the control groups, once a woman has been diagnosed as having a cutaneous melanoma, a subsequent pregnancy has no effect on recurrence rate or survival.

Duke Scholars

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Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1985

Volume

55

Issue

6

Start / End Page

1340 / 1344

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Prognosis
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Oncology & Carcinogenesis
  • Melanoma
  • Lymph Node Excision
  • Immunotherapy
  • Humans
 

Citation

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Chicago
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Reintgen, D. S., McCarty, K. S., Vollmer, R., Cox, E., & Seigler, H. F. (1985). Malignant melanoma and pregnancy. Cancer, 55(6), 1340–1344. https://doi.org/10.1002/1097-0142(19850315)55:6<1340::aid-cncr2820550630>3.0.co;2-t
Reintgen, D. S., K. S. McCarty, R. Vollmer, E. Cox, and H. F. Seigler. “Malignant melanoma and pregnancy.Cancer 55, no. 6 (March 15, 1985): 1340–44. https://doi.org/10.1002/1097-0142(19850315)55:6<1340::aid-cncr2820550630>3.0.co;2-t.
Reintgen DS, McCarty KS, Vollmer R, Cox E, Seigler HF. Malignant melanoma and pregnancy. Cancer. 1985 Mar 15;55(6):1340–4.
Reintgen, D. S., et al. “Malignant melanoma and pregnancy.Cancer, vol. 55, no. 6, Mar. 1985, pp. 1340–44. Pubmed, doi:10.1002/1097-0142(19850315)55:6<1340::aid-cncr2820550630>3.0.co;2-t.
Reintgen DS, McCarty KS, Vollmer R, Cox E, Seigler HF. Malignant melanoma and pregnancy. Cancer. 1985 Mar 15;55(6):1340–1344.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1985

Volume

55

Issue

6

Start / End Page

1340 / 1344

Location

United States

Related Subject Headings

  • Skin Neoplasms
  • Retrospective Studies
  • Prognosis
  • Pregnancy Complications, Neoplastic
  • Pregnancy
  • Oncology & Carcinogenesis
  • Melanoma
  • Lymph Node Excision
  • Immunotherapy
  • Humans