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Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma.

Publication ,  Journal Article
Stojadinovic, A; Allen, PJ; Clary, BM; Busam, KJ; Coit, DG
Published in: Ann Surg
January 2002

OBJECTIVE: To analyze a large, single-institution experience with routine frozen section (FS) of the sentinel lymph node (SLN) in patients with primary cutaneous melanoma. SUMMARY BACKGROUND DATA: Controversy exists over the utility of intraoperative FS analysis of the SLN in patients with primary cutaneous melanoma. METHODS: All patients with clinically node-negative cutaneous melanoma undergoing SLN biopsy from 1991 to 1999 were identified from a prospective database. All SLNs were examined by FS. Step-sectioning and immunohistochemistry of permanent section were performed for SLNs negative by FS. RESULTS: At least one SLN was identified in 98% (360/368) of patients. There were 74 (20%) SLNs positive on permanent section; FS was positive in 59% of these. The accuracy, sensitivity, and specificity of FS were 92%, 59%, and 100%. Because isolated recurrence developed in six patients in the nodal basin in which the SLN was negative, the failure rate was 1.7%. The false-negative rate for SLN biopsy was 7.5%. CONCLUSIONS: Because the prevalence of metastases within the SLN and sensitivity of FS analysis are low, routine use of FS for all patients undergoing SLN biopsy is not recommended.

Duke Scholars

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

January 2002

Volume

235

Issue

1

Start / End Page

92 / 98

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Sensitivity and Specificity
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Melanoma
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stojadinovic, A., Allen, P. J., Clary, B. M., Busam, K. J., & Coit, D. G. (2002). Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. Ann Surg, 235(1), 92–98. https://doi.org/10.1097/00000658-200201000-00012
Stojadinovic, Alexander, Peter J. Allen, Bryan M. Clary, Klaus J. Busam, and Daniel G. Coit. “Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma.Ann Surg 235, no. 1 (January 2002): 92–98. https://doi.org/10.1097/00000658-200201000-00012.
Stojadinovic A, Allen PJ, Clary BM, Busam KJ, Coit DG. Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. Ann Surg. 2002 Jan;235(1):92–8.
Stojadinovic, Alexander, et al. “Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma.Ann Surg, vol. 235, no. 1, Jan. 2002, pp. 92–98. Pubmed, doi:10.1097/00000658-200201000-00012.
Stojadinovic A, Allen PJ, Clary BM, Busam KJ, Coit DG. Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma. Ann Surg. 2002 Jan;235(1):92–98.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

January 2002

Volume

235

Issue

1

Start / End Page

92 / 98

Location

United States

Related Subject Headings

  • Time Factors
  • Surgery
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Sensitivity and Specificity
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Melanoma
  • Male