Comparison of once-a-day and twice-a-day theophylline in asthma.


Journal Article

Sustained-release theophylline compounds given once (Uniphyl) or twice (Theodur) daily were compared in adult asthmatics. Following a single dose of oral medication, large and peripheral airways bronchodilation occurred; response to theophylline correlated significantly with the log plasma theophylline concentration. Cardiac output and stroke volume, measured noninvasively using the acetylene technique, also increased significantly. During maintenance therapy, both preparations caused similar improvements in pulmonary function and symptoms; however, side effects were less with once-daily therapy.

Full Text

Cited Authors

  • Fairshter, RD; Lowe, JE; Wilson, AF; Salness, K; Novey, HS

Published Date

  • January 1, 1986

Published In

Volume / Issue

  • 50 / 3

Start / End Page

  • 193 - 201

PubMed ID

  • 3797827

Pubmed Central ID

  • 3797827

Electronic International Standard Serial Number (EISSN)

  • 1423-0356

International Standard Serial Number (ISSN)

  • 0025-7931

Digital Object Identifier (DOI)

  • 10.1159/000194927


  • eng