A derivative of an ataxia-telangiectasia (A-T) cell line with normal radiosensitivity but A-T-like inhibition of DNA synthesis.


Journal Article

Ataxia-telangiectasia (A-T) cells are hypersensitive to the lethal effects of ionizing radiation and fail to inhibit DNA synthesis following radiation exposure. A cell line derived from an A-T line following DNA-mediated gene transfer has normal radiation sensitivity, but the kinetics of DNA synthesis after gamma-irradiation are similar to those of A-T cells.

Full Text

Cited Authors

  • Lehmann, AR; Arlett, CF; Burke, JF; Green, MH; James, MR; Lowe, JE

Published Date

  • April 1986

Published In

Volume / Issue

  • 49 / 4

Start / End Page

  • 639 - 643

PubMed ID

  • 3485605

Pubmed Central ID

  • 3485605

International Standard Serial Number (ISSN)

  • 0020-7616

Digital Object Identifier (DOI)

  • 10.1080/09553008514552881


  • eng