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Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.

Publication ,  Journal Article
Chen, EP; Akhter, SA; Bittner, HB; Koch, WJ; Davis, RD; Van Trigt, P
Published in: Ann Thorac Surg
April 1999

BACKGROUND: Chronic pulmonary hypertension can lead to compensatory changes in the right ventricle. In this study, the adaptive mechanisms of the right ventricle in the setting of pulmonary hypertension were assessed at the molecular and functional level using a canine model of monocrotaline pyrrole-induced pulmonary hypertension. METHODS: Animals underwent pulmonary artery catheterization to measure pulmonary hemodynamics before and 8 weeks after an injection of monocrotaline pyrrole, 3 mg/kg (n = 8) or placebo (n = 8) (controls). Systolic function was assessed with load-insensitive means (preload-recruitable stroke work). Myocardial biopsy specimens were collected to analyze membrane alpha1- and beta-adrenergic receptor density and adenylate cyclase activity. RESULTS: Eight weeks after injection, significant increases in pulmonary hemodynamic indices were noted in monocrotaline-injected dogs. Significant increases in right ventricular preload-recruitable stroke work were also observed in these animals compared with controls and occurred in association with significant increases in right ventricular alpha1- and beta-adrenergic receptor density and isoproterenol hydrochloride-stimulated adenylate cyclase activity. No significant differences in basal adenylate cyclase activity in the right ventricle were noted between the two groups. CONCLUSIONS: These data suggest that alterations in right ventricular function in the setting of chronic pulmonary hypertension may partially be due to changes in myocardial adrenergic receptor signaling.

Duke Scholars

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

April 1999

Volume

67

Issue

4

Start / End Page

1053 / 1058

Location

Netherlands

Related Subject Headings

  • Ventricular Function, Right
  • Stroke Volume
  • Respiratory System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pulmonary Circulation
  • Myocardium
  • Monocrotaline
  • Hypertension, Pulmonary
  • Hemodynamics
 

Citation

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Chen, E. P., Akhter, S. A., Bittner, H. B., Koch, W. J., Davis, R. D., & Van Trigt, P. (1999). Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. Ann Thorac Surg, 67(4), 1053–1058. https://doi.org/10.1016/s0003-4975(99)00142-3
Chen, E. P., S. A. Akhter, H. B. Bittner, W. J. Koch, R. D. Davis, and P. Van Trigt. “Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.Ann Thorac Surg 67, no. 4 (April 1999): 1053–58. https://doi.org/10.1016/s0003-4975(99)00142-3.
Chen EP, Akhter SA, Bittner HB, Koch WJ, Davis RD, Van Trigt P. Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. Ann Thorac Surg. 1999 Apr;67(4):1053–8.
Chen, E. P., et al. “Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension.Ann Thorac Surg, vol. 67, no. 4, Apr. 1999, pp. 1053–58. Pubmed, doi:10.1016/s0003-4975(99)00142-3.
Chen EP, Akhter SA, Bittner HB, Koch WJ, Davis RD, Van Trigt P. Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension. Ann Thorac Surg. 1999 Apr;67(4):1053–1058.
Journal cover image

Published In

Ann Thorac Surg

DOI

ISSN

0003-4975

Publication Date

April 1999

Volume

67

Issue

4

Start / End Page

1053 / 1058

Location

Netherlands

Related Subject Headings

  • Ventricular Function, Right
  • Stroke Volume
  • Respiratory System
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Pulmonary Circulation
  • Myocardium
  • Monocrotaline
  • Hypertension, Pulmonary
  • Hemodynamics