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Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats.

Publication ,  Journal Article
Okumura, T; Pappas, TN; Taylor, IL
Published in: Neurosci Lett
August 29, 1994

In the present study, we evaluated the effects of central administration of pancreatic polypeptide (PP) on gastric emptying of a liquid meal in conscious rats using a phenol red method. Intracisternal injection of PP (0.5-2.0 micrograms) speeds gastric emptying of a test meal in a dose-dependent manner. In contrast, i.p. injection of PP at the same doses inhibited gastric emptying in a dose-related fashion. Bilateral gastric branch vagotomy abolished the increase in gastric emptying evoked by intracisternal PP. These results demonstrate that PP speeds gastric emptying through the vagal system when given centrally but slows emptying when given peripherally.

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Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

August 29, 1994

Volume

178

Issue

1

Start / End Page

167 / 170

Location

Ireland

Related Subject Headings

  • Vagotomy
  • Rats, Sprague-Dawley
  • Rats
  • Pancreatic Polypeptide
  • Microinjections
  • Male
  • Injections, Intraperitoneal
  • Gastric Emptying
  • Dose-Response Relationship, Drug
  • Brain Stem
 

Citation

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Okumura, T., Pappas, T. N., & Taylor, I. L. (1994). Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats. Neurosci Lett, 178(1), 167–170. https://doi.org/10.1016/0304-3940(94)90316-6
Okumura, T., T. N. Pappas, and I. L. Taylor. “Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats.Neurosci Lett 178, no. 1 (August 29, 1994): 167–70. https://doi.org/10.1016/0304-3940(94)90316-6.
Okumura T, Pappas TN, Taylor IL. Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats. Neurosci Lett. 1994 Aug 29;178(1):167–70.
Okumura, T., et al. “Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats.Neurosci Lett, vol. 178, no. 1, Aug. 1994, pp. 167–70. Pubmed, doi:10.1016/0304-3940(94)90316-6.
Okumura T, Pappas TN, Taylor IL. Intracisternal injection of pancreatic polypeptide stimulates gastric emptying in rats. Neurosci Lett. 1994 Aug 29;178(1):167–170.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

August 29, 1994

Volume

178

Issue

1

Start / End Page

167 / 170

Location

Ireland

Related Subject Headings

  • Vagotomy
  • Rats, Sprague-Dawley
  • Rats
  • Pancreatic Polypeptide
  • Microinjections
  • Male
  • Injections, Intraperitoneal
  • Gastric Emptying
  • Dose-Response Relationship, Drug
  • Brain Stem