Neuropeptide Y functions as a physiologic regulator of cephalic phase acid secretion.

Journal Article

Neuropeptide Y (NPY) has been established as a potent orexigenic peptide, and recent studies suggest that NPY stimulates cephalic phase secretion as well. However, it is not known whether NPY's effects are pharmacologic or physiologic. In order to determine the physiologic significance of NPY, we examined the effects of two putative NPY receptor antagonists, PYX-1 and PYX-2, on sham feeding and gastric acid secretion in dogs. Our results demonstrate that intracerebroventricular (i.c.v.) injection of PYX-1 and PYX-2 at 1000 pmol/kg doses significantly suppresses the gastric acid response to sham feeding in dogs. The volumes sham fed were not significantly altered with i.c.v. administration of the antagonists. Peripheral administration did not affect acid secretion nor sham feeding volumes. Our data suggest that central administration of the novel NPY antagonists, PYX-1 and PYX-2, results in significant suppression of acid secretion in dogs. This supports our hypothesis that NPY functions as a physiologic modulator of cephalic phase acid secretion.

Full Text

Duke Authors

Cited Authors

  • Lee, MC; Lawson, DC; Pappas, TN

Published Date

  • August 4, 1994

Published In

Volume / Issue

  • 52 / 3

Start / End Page

  • 227 - 234

PubMed ID

  • 7800854

International Standard Serial Number (ISSN)

  • 0167-0115

Language

  • eng

Conference Location

  • Netherlands