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Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats.

Publication ,  Other
Okumura, T; Fukagawa, K; Tso, P; Taylor, IL; Pappas, TN
Published in: Gastroenterology
December 1994

BACKGROUND/AIMS: Fat feeding increases not only serum but also cerebrospinal fluid concentration of apolipoprotein (apo) A-IV, a protein produced mainly by the small intestine in the rat. We hypothesized that apo A-IV may have a central effect on gastric secretion. METHODS: Gastric juice was collected by the pylorus ligation method. Rats underwent pylorus ligation and received intracisternal injection of apo A-IV under brief isoflurane anesthesia. Two hours after the injection, gastric juice was collected and gastric acid output determined. RESULTS: Intracisternal injection of 0.5 microgram apo A-IV had no effect on gastric secretion. However, gastric acid secretion was significantly inhibited by intracisternal injection of 1 microgram apo A-IV. Furthermore, intracisternal administration of higher doses of apo A-IV (2.0 and 4.0 microgram) resulted in greater inhibition of gastric acid secretion in a dose-dependent manner. On the contrary, 4 micrograms of apo A-I intracisternally injected failed to inhibit gastric acid secretion. Intraperitoneal administration of 15 micrograms of apo A-IV did not alter gastric secretion. CONCLUSIONS: These results suggest that apo A-IV may act in the brain to inhibit gastric acid secretion. Apo A-IV might be a central enterogastrone, which is a gastric inhibitor produced by the small intestine in response to fat feeding.

Duke Scholars

Published In

Gastroenterology

DOI

ISSN

0016-5085

Publication Date

December 1994

Volume

107

Issue

6

Start / End Page

1861 / 1864

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pyloric Antrum
  • Male
  • Ligation
  • Injections, Intraperitoneal
  • Injections
  • Gastroenterology & Hepatology
  • Gastric Mucosa
  • Gastric Acid
 

Citation

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Okumura, T., Fukagawa, K., Tso, P., Taylor, I. L., & Pappas, T. N. (1994). Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats. Gastroenterology. United States. https://doi.org/10.1016/0016-5085(94)90833-8
Okumura, T., K. Fukagawa, P. Tso, I. L. Taylor, and T. N. Pappas. “Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats.Gastroenterology, December 1994. https://doi.org/10.1016/0016-5085(94)90833-8.
Okumura T, Fukagawa K, Tso P, Taylor IL, Pappas TN. Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats. Vol. 107, Gastroenterology. 1994. p. 1861–4.
Okumura, T., et al. “Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats.Gastroenterology, vol. 107, no. 6, Dec. 1994, pp. 1861–64. Pubmed, doi:10.1016/0016-5085(94)90833-8.
Okumura T, Fukagawa K, Tso P, Taylor IL, Pappas TN. Intracisternal injection of apolipoprotein A-IV inhibits gastric secretion in pylorus-ligated conscious rats. Gastroenterology. 1994. p. 1861–1864.
Journal cover image

Published In

Gastroenterology

DOI

ISSN

0016-5085

Publication Date

December 1994

Volume

107

Issue

6

Start / End Page

1861 / 1864

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pyloric Antrum
  • Male
  • Ligation
  • Injections, Intraperitoneal
  • Injections
  • Gastroenterology & Hepatology
  • Gastric Mucosa
  • Gastric Acid