The use of somatostatin and its analogs in the treatment of surgical disorders.

Journal Article (Journal Article;Review)

Somatostatin is a naturally occurring peptide with a wide spectrum of biologic actions, most of which are inhibitory in nature. It has wide distribution, and within the gastrointestinal tract is is found in the pancreas, the stomach, intestinal mucosa, and myenteric neurons. It appears to function as a classic circulating hormone, as well as both a paracrine or locally acting agent and a neurocrine agent. Because of its inhibitory actions on gut endocrine, secretory, and motor functions, it has potential applicability in the treatment of a variety of disorders of interest to the surgeon. Indeed, it has been used successfully in the management of upper gastrointestinal hemorrhage, secretory diarrhea, short bowel syndrome, pancreatitis, gastrointestinal fistulas, and peptide-secreting tumors of the gut (apudomas). This review discusses physiology, pathophysiology, and therapeutic applications of somatostatin that may be important in surgical practice.

Full Text

Duke Authors

Cited Authors

  • Mulvihill, S; Pappas, TN; Passaro, E; Debas, HT

Published Date

  • September 1986

Published In

Volume / Issue

  • 100 / 3

Start / End Page

  • 467 - 476

PubMed ID

  • 2874618

International Standard Serial Number (ISSN)

  • 0039-6060


  • eng

Conference Location

  • United States