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Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.

Publication ,  Other
Okumura, T; Taylor, IL; Fukagawa, K; Tso, P; Pappas, TN
Published in: Brain Res
February 27, 1995

We have recently reported that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central nervous system using Sprague-Dawley rats. Intracisternal injection of apo A-IV dose-dependently (2.0-4.0 micrograms/rat) reduced the severity of gastric mucosal lesions induced by intravenous injection of 2-deoxy-D-glucose or subcutaneous administration of indomethacine. A higher dose (15 micrograms) of apo A-IV injected intraperitoneally failed to inhibit the development of gastric mucosal damage evoked by these ulcerogenic agents. These results suggest for the first time that apo A-IV has an anti-ulcer action through a central mechanism.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

February 27, 1995

Volume

673

Issue

1

Start / End Page

153 / 156

Location

Netherlands

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Peptic Ulcer
  • Neurology & Neurosurgery
  • Male
  • Injections, Spinal
  • Indomethacin
  • Dose-Response Relationship, Drug
  • Deoxyglucose
  • Brain
 

Citation

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Okumura, T., Taylor, I. L., Fukagawa, K., Tso, P., & Pappas, T. N. (1995). Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat. Brain Res. Netherlands. https://doi.org/10.1016/0006-8993(94)01432-h
Okumura, T., I. L. Taylor, K. Fukagawa, P. Tso, and T. N. Pappas. “Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.Brain Res, February 27, 1995. https://doi.org/10.1016/0006-8993(94)01432-h.
Okumura T, Taylor IL, Fukagawa K, Tso P, Pappas TN. Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat. Vol. 673, Brain Res. 1995. p. 153–6.
Okumura, T., et al. “Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.Brain Res, vol. 673, no. 1, 27 Feb. 1995, pp. 153–56. Pubmed, doi:10.1016/0006-8993(94)01432-h.
Okumura T, Taylor IL, Fukagawa K, Tso P, Pappas TN. Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat. Brain Res. 1995. p. 153–156.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

February 27, 1995

Volume

673

Issue

1

Start / End Page

153 / 156

Location

Netherlands

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Peptic Ulcer
  • Neurology & Neurosurgery
  • Male
  • Injections, Spinal
  • Indomethacin
  • Dose-Response Relationship, Drug
  • Deoxyglucose
  • Brain