Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.

Other Article (Journal Article)

We have recently reported that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central nervous system using Sprague-Dawley rats. Intracisternal injection of apo A-IV dose-dependently (2.0-4.0 micrograms/rat) reduced the severity of gastric mucosal lesions induced by intravenous injection of 2-deoxy-D-glucose or subcutaneous administration of indomethacine. A higher dose (15 micrograms) of apo A-IV injected intraperitoneally failed to inhibit the development of gastric mucosal damage evoked by these ulcerogenic agents. These results suggest for the first time that apo A-IV has an anti-ulcer action through a central mechanism.

Full Text

Duke Authors

Cited Authors

  • Okumura, T; Taylor, IL; Fukagawa, K; Tso, P; Pappas, TN

Published Date

  • February 27, 1995

Published In

Volume / Issue

  • 673 / 1

Start / End Page

  • 153 - 156

PubMed ID

  • 7757469

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(94)01432-h


  • eng

Conference Location

  • Netherlands