Apolipoprotein A-IV acts centrally in the brain to reduce the severity of gastric ulceration in the rat.
Other Article (Journal Article)
We have recently reported that apolipoprotein A-IV (apo A-IV), a protein associated with lipoproteins, acts in the brain to inhibit gastric acid secretion. In the present study, we determined whether or not apo A-IV has an anti-ulcer action via the central nervous system using Sprague-Dawley rats. Intracisternal injection of apo A-IV dose-dependently (2.0-4.0 micrograms/rat) reduced the severity of gastric mucosal lesions induced by intravenous injection of 2-deoxy-D-glucose or subcutaneous administration of indomethacine. A higher dose (15 micrograms) of apo A-IV injected intraperitoneally failed to inhibit the development of gastric mucosal damage evoked by these ulcerogenic agents. These results suggest for the first time that apo A-IV has an anti-ulcer action through a central mechanism.
Full Text
Duke Authors
Cited Authors
- Okumura, T; Taylor, IL; Fukagawa, K; Tso, P; Pappas, TN
Published Date
- February 27, 1995
Published In
Volume / Issue
- 673 / 1
Start / End Page
- 153 - 156
PubMed ID
- 7757469
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/0006-8993(94)01432-h
Language
- eng
Conference Location
- Netherlands