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Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.

Publication ,  Journal Article
Okumura, T; Pappas, TN; Taylor, IL
Published in: Dig Dis Sci
November 1994

The present study was carried out to investigate the central effects of pancreatic polypeptide on gastric secretion and gastric ulcer formation in conscious rats. Intracisternal injection of rat pancreatic polypeptide (62.5, 250, and 1000 ng/rat) into pylorus-ligated rats resulted in a dose-dependent stimulation of gastric acid and pepsin secretion. In contrast, intraperitoneal injection of even higher doses of pancreatic polypeptide (250, 1000, and 2500 ng/rat) failed to increase gastric secretion. This stimulatory effect of centrally administered pancreatic polypeptide was completely blocked by vagotomy and by pretreatment with atropine. Intracisternal injection of PP (500-2000 ng/rat) dose-dependently increased the severity of gastric lesions induced by 2-deoxy-D-glucose or indomethacin. In contrast, intraperitoneal injection of PP failed to increase the severity of the gastric lesions induced by 2-deoxy-D-glucose or indomethacin. These results indicate that pancreatic polypeptide is capable of acting centrally in the brain to stimulate gastric acid and pepsin secretion through a vagal, muscarinic pathway and in so doing exerts an ulcerogenic action on the gastric mucosa.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

November 1994

Volume

39

Issue

11

Start / End Page

2398 / 2406

Location

United States

Related Subject Headings

  • Vagotomy
  • Stomach Ulcer
  • Rats, Sprague-Dawley
  • Rats
  • Pepsin A
  • Pancreatic Polypeptide
  • Male
  • Indomethacin
  • Gastroenterology & Hepatology
  • Gastric Mucosa
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Okumura, T., Pappas, T. N., & Taylor, I. L. (1994). Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats. Dig Dis Sci, 39(11), 2398–2406. https://doi.org/10.1007/BF02087657
Okumura, T., T. N. Pappas, and I. L. Taylor. “Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.Dig Dis Sci 39, no. 11 (November 1994): 2398–2406. https://doi.org/10.1007/BF02087657.
Okumura, T., et al. “Stimulation of gastric secretion and enhanced gastric mucosal damage following central administration of pancreatic polypeptide (PP) in rats.Dig Dis Sci, vol. 39, no. 11, Nov. 1994, pp. 2398–406. Pubmed, doi:10.1007/BF02087657.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

November 1994

Volume

39

Issue

11

Start / End Page

2398 / 2406

Location

United States

Related Subject Headings

  • Vagotomy
  • Stomach Ulcer
  • Rats, Sprague-Dawley
  • Rats
  • Pepsin A
  • Pancreatic Polypeptide
  • Male
  • Indomethacin
  • Gastroenterology & Hepatology
  • Gastric Mucosa