Intracerebroventricular neuropeptide Y stimulates bile secretion via a vagal mechanism.

Journal Article (Journal Article)

UNLABELLED: The effect of intracerebroventricular injection of neuropeptide Y on biliary secretion was studied in conscious dogs, prepared with gastric and duodenal fistulas and cerebroventricular guides. Bile secretion was increased in a dose-dependent fashion by intracerebroventricular neuropeptide Y. The peak increase was seen after 500 pM/kg of neuropeptide Y which resulted in a 30 x 2% increase in bile flow over the period 30-150 minutes after injection. ( CONTROL: 23 x 2 (1 x 2) ml/2 hours; neuropeptide Y 500 pM/kg: 30 x 5 (1 x 1) ml/2 hours). Biliary lipid composition was not altered significantly but bicarbonate output was increased at all doses tested. Intravenous infusion of neuropeptide Y (1000 pM) for 1 hour had no significant effect. Intracerebroventricular neuropeptide Y (1000 pM/250-300 mg body weight) also increased bile flow in urethane-anaesthetised rats. This effect was abolished by cervical vagotomy. The demonstration of a central stimulation of alkaline bile flow suggests that bile secretion may be subject to central modulation.

Full Text

Duke Authors

Cited Authors

  • Farouk, M; Geoghegan, JG; Pruthi, RS; Thomson, HJ; Pappas, TN; Meyers, WC

Published Date

  • November 1992

Published In

Volume / Issue

  • 33 / 11

Start / End Page

  • 1562 - 1565

PubMed ID

  • 1452085

Pubmed Central ID

  • PMC1379547

International Standard Serial Number (ISSN)

  • 0017-5749

Digital Object Identifier (DOI)

  • 10.1136/gut.33.11.1562


  • eng

Conference Location

  • England