Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs.

Journal Article (Journal Article)

Insulin release following intravenous administration of an amino acid solution with and without a simultaneous infusion of varying amounts of porcine gastric inhibitory polypeptide (GIP) was studied in dogs. Group I received a 10-amino acid mixture (300 mosmol/kg iv) at 16.6 ml/min for 1 h; group II, amino acid mixture plus 0.5 micrograms.kg-1.h-1 porcine GIP; group III, amino acid mixture plus 1.0 micrograms.kg-1.h-1 of GIP; group IV (a and b) received either 0.5 or 1.0 micrograms.kg-1.h-1 of GIP alone. Compared to group I, groups II and III had a greater insulin response during the first 30 min of the infusion. Group] IV (a and b) showed no insulin release. Glucose concentrations showed no significant change in all groups. From these results, it is concluded that insulin release after intravenous infusion of an amino acid mixture plus GIP is greater than after amino acids or GIP alone. It appears that this effect is more pronounced in the early phase of insulin release.

Full Text

Duke Authors

Cited Authors

  • Yovos, JG; O'Dorisio, TM; Pappas, TN; Cataland, S; Thomas, FB; Mekhjian, H; Carey, LC

Published Date

  • January 1, 1982

Published In

Volume / Issue

  • 242 / 1

Start / End Page

  • E53 - E58

PubMed ID

  • 7036753

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpendo.1982.242.1.E53


  • eng

Conference Location

  • United States