Pancreatic polypeptide in acute pancreatitis and small-bowel infarction in dogs.

Journal Article (Journal Article)

Serum and urine concentrations of pancreatic polypeptide (PP) were measured during experimental acute hemorrhagic pancreatitis and small-bowel infarction in dogs. The mean serum PP concentration in animals with pancreatitis increased markedly after 1 hr and remained elevated, while the mean serum PP concentration in the animals with infarction showed a late trend to increase. The urine PP concentration in pancreatitis increased nonsignificantly, whereas, during bowel infarction, there was no increase. In the infarction group, PP clearance correlated with the serum PP concentration. During pancreatitis, PP was cleared independently of the serum PP concentration. The results suggest that during acute hemorrhagic pancreatitis there is an acute release of PP related to immediate cell injury in the pancreas. The high serum concentration of PP may lead to an override of the normal renal handling of PP. In small-bowel infarction there may be a delayed mode of PP release.

Full Text

Duke Authors

Cited Authors

  • Pappas, TN; Yovos, JG; Ellison, EC; O'Dorisio, TM; Cataland, S; Pace, WG; Carey, LC

Published Date

  • November 1, 1981

Published In

Volume / Issue

  • 26 / 11

Start / End Page

  • 1013 - 1018

PubMed ID

  • 7297370

International Standard Serial Number (ISSN)

  • 0163-2116

Digital Object Identifier (DOI)

  • 10.1007/BF01314764


  • eng

Conference Location

  • United States