Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.

Published

Journal Article

The synthetic mammalian bombesin-like peptides, canine gastrin releasing peptide 27, 23 and 10, and porcine gastrin releasing peptide 27 were compared with amphibian bombesin 14 and 10 during intravenous infusions into six conscious dogs with chronic gastric cannulae. Gastrin and gastrin releasing peptide were measured in peripherally sampled venous blood by radioimmunoassay and gastric acid secretions were collected. All forms of gastrin releasing peptide stimulated gastrin release and gastric acid secretion in a dose-dependent manner. The larger canine and porcine peptides were more potent than the decapeptide. Bombesin 14 was more potent than bombesin 10. A rise in the venous concentration of immunoreactive gastrin releasing peptide of only 20 fmol ml-1 stimulated gastrin release to about 50% of maximal. Gastrin releasing peptide 10 was cleared from the circulation three times faster than the larger forms and this may account for the apparent differences in potency.

Full Text

Duke Authors

Cited Authors

  • Bunnett, NW; Clark, B; Debas, HT; Del Milton, RC; Kovacs, TO; Orloff, MS; Pappas, TN; Reeve, JR; Rivier, JE; Walsh, JH

Published Date

  • August 1985

Published In

Volume / Issue

  • 365 /

Start / End Page

  • 121 - 130

PubMed ID

  • 3839849

Pubmed Central ID

  • 3839849

International Standard Serial Number (ISSN)

  • 0022-3751

Digital Object Identifier (DOI)

  • 10.1113/jphysiol.1985.sp015762

Language

  • eng

Conference Location

  • England