The effect of somatostatin on experimental intestinal obstruction.

Journal Article (Journal Article)

The effect of somatostatin (SS-14) was tested in an anesthetized rabbit model of closed-loop ileal obstruction. Experimental groups included (1) immediate treatment (N = 6) receiving SS-14 2,000 pmol X kg-1 X h-1 intravenously (I.V.) beginning at the time of ileal obstruction, (2) delayed treatment (N = 5) receiving SS-14 beginning 6 hours following ileal obstruction, and (3) control (N = 6) receiving only hydration. After 24 hours, all rabbits were killed. Significantly decreased intestinal luminal volume and sodium and potassium output was observed with both immediate and delayed SS-14 treatment when compared to control. Additionally, the gross and microscopic pathologic features of intestinal distension, inflammation, and necrosis seen in control rabbits were absent in rabbits treated with SS-14. The known broad spectrum of physiologic activity of SS-14 on the gastrointestinal tract appeared beneficial in this rabbit model of intestinal obstruction.

Full Text

Duke Authors

Cited Authors

  • Mulvihill, SJ; Pappas, TN; Fonkalsrud, EW; Debas, HT

Published Date

  • February 1, 1988

Published In

Volume / Issue

  • 207 / 2

Start / End Page

  • 169 - 173

PubMed ID

  • 2893593

Pubmed Central ID

  • PMC1493368

International Standard Serial Number (ISSN)

  • 0003-4932

Digital Object Identifier (DOI)

  • 10.1097/00000658-198802000-00009


  • eng

Conference Location

  • United States