A canine model of gastroesophageal reflux disease (GERD).

Journal Article (Journal Article)

BACKGROUND: Although a variety of antireflux procedures and medications are used to treat gastroesophageal reflux disease (GERD), reliable large-animal models of GERD that can be used to objectively compare the efficacy of these treatments are lacking. METHODS: Esophageal manometry and 24-h gastroesophageal pH monitoring with event data were performed in 18 mongrel dogs with a cervical esophagopexy. We then calculated a modified DeMeester score: The Duke Canine reflux score (DCR). Thereafter, the animals underwent a 4-cm anterior distal esophageal myotomy, incision of the left diaphragmatic crus, and intrathoracic gastric cardiopexy. Postoperative 24-h pH and manometry were obtained 2 weeks later. RESULTS: The postoperative 24-h pH results showed a significant increase in the mean DCR score (5.9 +/- 4.5 vs 84.9 +/- 56.1, p < 0.0002), and manometry indicated a significant decrease in mean lower esophageal sphincter (LES) pressure (7.1 +/- 2.9 vs 3.2 +/- 2.5 mmHg, p < 0.0001). CONCLUSION: This technique reliably creates a canine model of GERD.

Full Text

Duke Authors

Cited Authors

  • McMahon, RL; Ali, A; Chekan, EG; Clary, EM; Garcia-Oria, MJ; Fina, MC; McRae, RL; Ko, A; Gandsas, A; Pappas, TN; Eubanks, WS

Published Date

  • January 2002

Published In

Volume / Issue

  • 16 / 1

Start / End Page

  • 67 - 74

PubMed ID

  • 11961608

Electronic International Standard Serial Number (EISSN)

  • 1432-2218

Digital Object Identifier (DOI)

  • 10.1007/s004640080153


  • eng

Conference Location

  • Germany