Skip to main content
Journal cover image

Impaired gastric motor activity after abdominal surgery in rats.

Publication ,  Journal Article
Fukuda, H; Tsuchida, D; Koda, K; Miyazaki, M; Pappas, TN; Takahashi, T
Published in: Neurogastroenterol Motil
April 2005

Postoperative ileus (POI) is a transient bowel dysmotility that occurs following abdominal surgery. Several mechanisms have been proposed such as neural reflex and inflammatory changes. We focused on gastric motility after abdominal surgery in rats. To investigate the time course of gastric motility after surgery, gastric motility was continuously recorded before, during and after surgery. After laparotomy, terminal ileum was manipulated for 10 min. Gastric motility was recorded by a strain gauge transducer implanted on the serosal surface of the stomach. To investigate whether peripheral sympathetic nerve is involved in the pathogenesis of POI, effects of guanethidine and celiac ganglionectomy were tested on the postoperative gastric motility. Although isoflurane anaesthesia reduced the gastric motility to 40%, the motility recovered immediately when isoflurane was withdrawn. Intestinal manipulation reduced the postoperative gastric motility for 3-24 h after surgery, compared with preoperative levels. Guanethidine administration and celiac ganglionectomy restored the impaired gastric motility. Feeding increased the gastric motility in each group. It is suggested that the pathogenesis of postoperative gastric ileus induced by intestinal manipulation involves viscero-sympathetic pathways. Intestinal manipulation causes impaired gastric motility via inhibitory sympathetic efferent pathway. Feeding may improve the postoperative gastric motility.

Duke Scholars

Published In

Neurogastroenterol Motil

DOI

ISSN

1350-1925

Publication Date

April 2005

Volume

17

Issue

2

Start / End Page

245 / 250

Location

England

Related Subject Headings

  • Stomach
  • Rats
  • Postoperative Complications
  • Male
  • Ileus
  • Guanethidine
  • Gastrointestinal Motility
  • Gastroenterology & Hepatology
  • Ganglionectomy
  • Ganglia, Sympathetic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fukuda, H., Tsuchida, D., Koda, K., Miyazaki, M., Pappas, T. N., & Takahashi, T. (2005). Impaired gastric motor activity after abdominal surgery in rats. Neurogastroenterol Motil, 17(2), 245–250. https://doi.org/10.1111/j.1365-2982.2004.00602.x
Fukuda, H., D. Tsuchida, K. Koda, M. Miyazaki, T. N. Pappas, and T. Takahashi. “Impaired gastric motor activity after abdominal surgery in rats.Neurogastroenterol Motil 17, no. 2 (April 2005): 245–50. https://doi.org/10.1111/j.1365-2982.2004.00602.x.
Fukuda H, Tsuchida D, Koda K, Miyazaki M, Pappas TN, Takahashi T. Impaired gastric motor activity after abdominal surgery in rats. Neurogastroenterol Motil. 2005 Apr;17(2):245–50.
Fukuda, H., et al. “Impaired gastric motor activity after abdominal surgery in rats.Neurogastroenterol Motil, vol. 17, no. 2, Apr. 2005, pp. 245–50. Pubmed, doi:10.1111/j.1365-2982.2004.00602.x.
Fukuda H, Tsuchida D, Koda K, Miyazaki M, Pappas TN, Takahashi T. Impaired gastric motor activity after abdominal surgery in rats. Neurogastroenterol Motil. 2005 Apr;17(2):245–250.
Journal cover image

Published In

Neurogastroenterol Motil

DOI

ISSN

1350-1925

Publication Date

April 2005

Volume

17

Issue

2

Start / End Page

245 / 250

Location

England

Related Subject Headings

  • Stomach
  • Rats
  • Postoperative Complications
  • Male
  • Ileus
  • Guanethidine
  • Gastrointestinal Motility
  • Gastroenterology & Hepatology
  • Ganglionectomy
  • Ganglia, Sympathetic