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Surgical strategies and outcomes after induction therapy for non-small cell lung cancer.

Publication ,  Journal Article
Burfeind, WR; Harpole, DH
Published in: Semin Thorac Cardiovasc Surg
2005

Surgery as the sole therapy for locally advanced non-small cell lung cancer (NSCLC) is usually not curative. Adjuvant chemotherapy has been evaluated by several randomized Phase III trials and found to confer a survival benefit over surgery alone for stage IB-IIIA NSCLC. Induction therapy applies a cytoreductive and systemic therapy before definitive locoregional therapy. Theoretical advantages include improved diffusion of chemotherapy agents into the tumor, improved compliance, and a higher complete resection rate. Results from multiple Phase II and III studies have been encouraging, but the role of surgery after induction therapy remains inconclusively defined. Randomized trials are underway to better define the role of induction therapy, and enrollment of patients into such trials should be encouraged.

Duke Scholars

Published In

Semin Thorac Cardiovasc Surg

DOI

ISSN

1043-0679

Publication Date

2005

Volume

17

Issue

3

Start / End Page

186 / 190

Location

United States

Related Subject Headings

  • Respiratory System
  • Radiotherapy, Adjuvant
  • Neoadjuvant Therapy
  • Lung Neoplasms
  • Humans
  • Chemotherapy, Adjuvant
  • Carcinoma, Non-Small-Cell Lung
  • Antineoplastic Combined Chemotherapy Protocols
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Chicago
ICMJE
MLA
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Burfeind, W. R., & Harpole, D. H. (2005). Surgical strategies and outcomes after induction therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg, 17(3), 186–190. https://doi.org/10.1053/j.semtcvs.2005.06.015
Burfeind, William R., and David H. Harpole. “Surgical strategies and outcomes after induction therapy for non-small cell lung cancer.Semin Thorac Cardiovasc Surg 17, no. 3 (2005): 186–90. https://doi.org/10.1053/j.semtcvs.2005.06.015.
Burfeind WR, Harpole DH. Surgical strategies and outcomes after induction therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2005;17(3):186–90.
Burfeind, William R., and David H. Harpole. “Surgical strategies and outcomes after induction therapy for non-small cell lung cancer.Semin Thorac Cardiovasc Surg, vol. 17, no. 3, 2005, pp. 186–90. Pubmed, doi:10.1053/j.semtcvs.2005.06.015.
Burfeind WR, Harpole DH. Surgical strategies and outcomes after induction therapy for non-small cell lung cancer. Semin Thorac Cardiovasc Surg. 2005;17(3):186–190.
Journal cover image

Published In

Semin Thorac Cardiovasc Surg

DOI

ISSN

1043-0679

Publication Date

2005

Volume

17

Issue

3

Start / End Page

186 / 190

Location

United States

Related Subject Headings

  • Respiratory System
  • Radiotherapy, Adjuvant
  • Neoadjuvant Therapy
  • Lung Neoplasms
  • Humans
  • Chemotherapy, Adjuvant
  • Carcinoma, Non-Small-Cell Lung
  • Antineoplastic Combined Chemotherapy Protocols
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology