Transplantation in the HIV+ patient.

Published

Journal Article (Review)

The historical exclusion from transplantation of HIV-infected people was based on the logical premise that immunosuppression required for organ transplantation would exacerbate an immunocompromised state. However, the prognosis for people with HIV infection has dramatically improved with the clinical use of highly active antiretroviral (ARV) therapy (HAART). Clinical trials of ARV agents have demonstrated significant virologic, immunologic and survival benefits associated with the use of protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) containing regimens, when combined with two nucleoside analogues. The incidence of opportunistic infections and hospitalizations has decreased with the use of HAART. In combination with historical data suggesting that a subpopulation of HIV+ transplant recipients tolerate immunosuppression and have allograft survival comparable to that of HIV- transplant recipients, these results indicate that the medical community should readdress HIV infection as a contraindication to transplantation.

Full Text

Duke Authors

Cited Authors

  • Kuo, PC; Stock, PG

Published Date

  • May 2001

Published In

Volume / Issue

  • 1 / 1

Start / End Page

  • 13 - 17

PubMed ID

  • 12095031

Pubmed Central ID

  • 12095031

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1034/j.1600-6143.2001.010104.x

Language

  • eng

Conference Location

  • United States