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Distinctive clinical features of portopulmonary hypertension.

Publication ,  Journal Article
Kuo, PC; Plotkin, JS; Johnson, LB; Howell, CD; Laurin, JM; Bartlett, ST; Rubin, LJ
Published in: Chest
October 1997

STUDY OBJECTIVE: To differentiate the cardiopulmonary profile of portopulmonary hypertension (PPHTN) from that of primary pulmonary hypertension and chronic liver disease. DESIGN: Retrospective survey. SETTING: Tertiary care center. PATIENTS: Thirty patients with cardiac catheterization-proven PPHTN were compared to 30 randomly selected patients with primary pulmonary hypertension alone and 30 patients with chronic liver disease alone necessitating consideration of liver transplantation (L-CONT). INTERVENTIONS: All patients underwent right heart catheterization, echocardiography, ECG, chest radiography, pulmonary function tests, ventilation-perfusion scanning, and room air arterial blood gas measurements. RESULTS: Patients with PPHTN exhibited elevated pulmonary pressures (mean pulmonary pressure, 48.6+/-2.1 mm Hg) and pulmonary vascular resistance (11.6+/-1.6 mm Hg/L/min/m2) with simultaneous elevation in the cardiac index (3.8+/-0.3 L/min/m2) and depression of systemic vascular resistance (24.9+/-1.7 mm Hg/L/min/m2). Arterial blood gas measurements indicate that PPHTN exhibits a significant accentuation of the chronic respiratory alkalosis (PCO2, 28.7+/-0.5 mm Hg) usually seen with chronic liver disease and pulmonary hypertension. In addition, patients with PPHTN have an increased alveolar-arterial gradient (27.0+/-2.7 mm Hg) when compared to patients with L-CONT, suggesting impaired gas exchange. CONCLUSIONS: PPHTN is associated with a unique clinical profile that possesses characteristics common to and exclusive of liver disease and primary pulmonary hypertension.

Duke Scholars

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

October 1997

Volume

112

Issue

4

Start / End Page

980 / 986

Location

United States

Related Subject Headings

  • Ventilation-Perfusion Ratio
  • Vascular Resistance
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests
  • Radiography
  • Pulmonary Gas Exchange
  • Pulmonary Artery
  • Oxygen
  • Middle Aged
 

Citation

APA
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Kuo, P. C., Plotkin, J. S., Johnson, L. B., Howell, C. D., Laurin, J. M., Bartlett, S. T., & Rubin, L. J. (1997). Distinctive clinical features of portopulmonary hypertension. Chest, 112(4), 980–986. https://doi.org/10.1378/chest.112.4.980
Kuo, P. C., J. S. Plotkin, L. B. Johnson, C. D. Howell, J. M. Laurin, S. T. Bartlett, and L. J. Rubin. “Distinctive clinical features of portopulmonary hypertension.Chest 112, no. 4 (October 1997): 980–86. https://doi.org/10.1378/chest.112.4.980.
Kuo PC, Plotkin JS, Johnson LB, Howell CD, Laurin JM, Bartlett ST, et al. Distinctive clinical features of portopulmonary hypertension. Chest. 1997 Oct;112(4):980–6.
Kuo, P. C., et al. “Distinctive clinical features of portopulmonary hypertension.Chest, vol. 112, no. 4, Oct. 1997, pp. 980–86. Pubmed, doi:10.1378/chest.112.4.980.
Kuo PC, Plotkin JS, Johnson LB, Howell CD, Laurin JM, Bartlett ST, Rubin LJ. Distinctive clinical features of portopulmonary hypertension. Chest. 1997 Oct;112(4):980–986.
Journal cover image

Published In

Chest

DOI

ISSN

0012-3692

Publication Date

October 1997

Volume

112

Issue

4

Start / End Page

980 / 986

Location

United States

Related Subject Headings

  • Ventilation-Perfusion Ratio
  • Vascular Resistance
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests
  • Radiography
  • Pulmonary Gas Exchange
  • Pulmonary Artery
  • Oxygen
  • Middle Aged