Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.
Journal Article (Journal Article;Review)
Dapsone, a sulfone antibiotic, has been increasingly used in solid-organ transplant recipients for the primary prevention of Pneumocystis carinii pneumonia, especially in patients with documented sulfa allergy. A known side effect of dapsone therapy, however, is methemoglobinemia, a condition leading to impaired tissue oxygen delivery. This report documents two cases of dapsone-induced methemoglobinemia in patients after solid organ transplantation with emphasis on the importance of clinical recognition and benefits of treatment. Further, the pathophysiology and causes of this condition are extensively reviewed.
- Plotkin, JS; Buell, JF; Njoku, MJ; Wilson, S; Kuo, PC; Bartlett, ST; Howell, C; Johnson, LB
- March 1997
- Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Volume / Issue
- 3 / 2
Start / End Page
- 149 - 152
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States