Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.
Publication
, Journal Article
Plotkin, JS; Buell, JF; Njoku, MJ; Wilson, S; Kuo, PC; Bartlett, ST; Howell, C; Johnson, LB
Published in: Liver Transpl Surg
March 1997
Dapsone, a sulfone antibiotic, has been increasingly used in solid-organ transplant recipients for the primary prevention of Pneumocystis carinii pneumonia, especially in patients with documented sulfa allergy. A known side effect of dapsone therapy, however, is methemoglobinemia, a condition leading to impaired tissue oxygen delivery. This report documents two cases of dapsone-induced methemoglobinemia in patients after solid organ transplantation with emphasis on the importance of clinical recognition and benefits of treatment. Further, the pathophysiology and causes of this condition are extensively reviewed.
Duke Scholars
Published In
Liver Transpl Surg
DOI
ISSN
1074-3022
Publication Date
March 1997
Volume
3
Issue
2
Start / End Page
149 / 152
Location
United States
Related Subject Headings
- Surgery
- Pneumonia, Pneumocystis
- Pancreas Transplantation
- Organ Transplantation
- Middle Aged
- Methemoglobinemia
- Liver Transplantation
- Kidney Transplantation
- Humans
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Plotkin, J. S., Buell, J. F., Njoku, M. J., Wilson, S., Kuo, P. C., Bartlett, S. T., … Johnson, L. B. (1997). Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review. Liver Transpl Surg, 3(2), 149–152. https://doi.org/10.1002/lt.500030207
Plotkin, J. S., J. F. Buell, M. J. Njoku, S. Wilson, P. C. Kuo, S. T. Bartlett, C. Howell, and L. B. Johnson. “Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.” Liver Transpl Surg 3, no. 2 (March 1997): 149–52. https://doi.org/10.1002/lt.500030207.
Plotkin JS, Buell JF, Njoku MJ, Wilson S, Kuo PC, Bartlett ST, et al. Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review. Liver Transpl Surg. 1997 Mar;3(2):149–52.
Plotkin, J. S., et al. “Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.” Liver Transpl Surg, vol. 3, no. 2, Mar. 1997, pp. 149–52. Pubmed, doi:10.1002/lt.500030207.
Plotkin JS, Buell JF, Njoku MJ, Wilson S, Kuo PC, Bartlett ST, Howell C, Johnson LB. Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review. Liver Transpl Surg. 1997 Mar;3(2):149–152.
Published In
Liver Transpl Surg
DOI
ISSN
1074-3022
Publication Date
March 1997
Volume
3
Issue
2
Start / End Page
149 / 152
Location
United States
Related Subject Headings
- Surgery
- Pneumonia, Pneumocystis
- Pancreas Transplantation
- Organ Transplantation
- Middle Aged
- Methemoglobinemia
- Liver Transplantation
- Kidney Transplantation
- Humans
- Female