Methemoglobinemia associated with dapsone treatment in solid organ transplant recipients: a two-case report and review.

Journal Article (Journal Article;Review)

Dapsone, a sulfone antibiotic, has been increasingly used in solid-organ transplant recipients for the primary prevention of Pneumocystis carinii pneumonia, especially in patients with documented sulfa allergy. A known side effect of dapsone therapy, however, is methemoglobinemia, a condition leading to impaired tissue oxygen delivery. This report documents two cases of dapsone-induced methemoglobinemia in patients after solid organ transplantation with emphasis on the importance of clinical recognition and benefits of treatment. Further, the pathophysiology and causes of this condition are extensively reviewed.

Full Text

Duke Authors

Cited Authors

  • Plotkin, JS; Buell, JF; Njoku, MJ; Wilson, S; Kuo, PC; Bartlett, ST; Howell, C; Johnson, LB

Published Date

  • March 1997

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 149 - 152

PubMed ID

  • 9346728

International Standard Serial Number (ISSN)

  • 1074-3022

Digital Object Identifier (DOI)

  • 10.1002/lt.500030207


  • eng

Conference Location

  • United States