The use of bilateral adult renal allografts - a method to optimize function from donor kidneys with suboptimal nephron mass.


Journal Article

Alternatives to traditional organ donor usage has allowed expansion of the organ donor pool to help compensate for the increasing disparity between recipients and donors. The use of bilateral adult renal transplants is a novel idea to salvage older donor kidneys with suboptimal nephron mass that would otherwise be destined for discard. Ten renal transplants were performed utilizing both kidneys from adult cadaver donors with diminished nephron mass determined by calculated glomerular filtration rate or biopsy evidence of significant glomerulosclerosis (>10%). Nine of ten (90%) recipients have satisfactory renal function at a mean follow-up of 7 months. The single case of graft failure was due to documented medical non-compliance. Mean serum creatinine at 6 months was 1.5 mg/dl. Mean measured creatinine clearance was 43.2+/-3.4. These preliminary findings suggest that the use of bilateral renal transplants provide satisfactory early function and allows salvage of older donor kidneys with suboptimal nephron mass.

Full Text

Duke Authors

Cited Authors

  • Johnson, LB; Kuo, PC; Dafoe, DC; Drachenberg, CB; Schweitzer, EJ; Alfrey, EJ; Ridge, LA; Salvatierra, P; Papadimitriou, JC; Mergner, WJ; Bartlett, ST

Published Date

  • April 27, 1996

Published In

Volume / Issue

  • 61 / 8

Start / End Page

  • 1261 - 1263

PubMed ID

  • 8610427

Pubmed Central ID

  • 8610427

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-199604270-00023


  • eng

Conference Location

  • United States