Cytoablative therapy with combined resection and cryosurgery for limited bilobar hepatic colorectal metastases.

Journal Article (Journal Article)

BACKGROUND: Cryosurgery can be employed in patients with unresectable hepatic metastases when the tumor size and the number of metastases are limited. However, local recurrence can result from incomplete ablation. We proposed a trial of complete cytoablation with a combined approach of cryosurgery and hepatic resection for patients with bilobar hepatic metastases. METHODS: Seven patients underwent cryosurgery alone (CRYO). Seven additional patients underwent combined resection and cryosurgery (CRYO+RES) for bilobar metastases. RESULTS: In the CRYO group, 5 of 7 patients had at least one centrally located tumor. All 5 of these patients had early recurrence at the site of ablation. In the CRYO+RES group complete ablation was achieved in 7 of 7. Two (28.6%) of these patients developed local recurrence. CONCLUSION: Cytoablation of hepatic metastases can be safely achieved with combined hepatic resection and cryosurgery in selected patients. Long-term survival data are necessary before advocating widespread application of this approach.

Full Text

Duke Authors

Cited Authors

  • Johnson, LB; Krebs, TL; Van Echo, D; Plotkin, JS; Njoku, M; Wong, JJ; Daly, BD; Kuo, PC

Published Date

  • December 1997

Published In

Volume / Issue

  • 174 / 6

Start / End Page

  • 610 - 613

PubMed ID

  • 9409583

International Standard Serial Number (ISSN)

  • 0002-9610

Digital Object Identifier (DOI)

  • 10.1016/s0002-9610(97)00176-1


  • eng

Conference Location

  • United States