The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family.
Publication
, Journal Article
Lu, CS; Chang, HC; Kuo, PC; Liu, YL; Wu, WS; Weng, YH; Yen, TC; Chou, YH
Published in: Parkinsonism & related disorders
August 2004
We report a parkinsonian phenotype of spinocerebellar ataxia type 3 (SCA3) in three female sibs from one Taiwanese family, found in a genetic analysis of 60 patients from 49 families with familial parkinsonism. Initially, all three patients presented with early onset resting tremor, rigidity, bradykinesia, and good response to levodopa. In the later stages, peripheral neuropathy developed in one sib and mild ataxia in another one. Decreased concentration of dopamine transporter in the striatum was demonstrated by (99m)Tc-TRODAT-1 SPECT imaging in the two sibs studied. Therefore, SCA3 should be considered as an important etiology of familial parkinsonism.
Duke Scholars
Published In
Parkinsonism & related disorders
ISSN
1353-8020
Publication Date
August 2004
Volume
10
Issue
6
Start / End Page
369 / 373
Location
england
Related Subject Headings
- Neurology & Neurosurgery
- 1702 Cognitive Sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Lu, C. S., Chang, H. C., Kuo, P. C., Liu, Y. L., Wu, W. S., Weng, Y. H., … Chou, Y. H. (2004). The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family. Parkinsonism & Related Disorders, 10(6), 369–373.
Lu, C. S., H. C. Chang, P. C. Kuo, Y. L. Liu, W. S. Wu, Y. H. Weng, T. C. Yen, and Y. H. Chou. “The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family.” Parkinsonism & Related Disorders 10, no. 6 (August 2004): 369–73.
Lu CS, Chang HC, Kuo PC, Liu YL, Wu WS, Weng YH, et al. The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family. Parkinsonism & related disorders. 2004 Aug;10(6):369–73.
Lu, C. S., et al. “The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family.” Parkinsonism & Related Disorders, vol. 10, no. 6, Aug. 2004, pp. 369–73.
Lu CS, Chang HC, Kuo PC, Liu YL, Wu WS, Weng YH, Yen TC, Chou YH. The parkinsonian phenotype of spinocerebellar ataxia type 3 in a Taiwanese family. Parkinsonism & related disorders. 2004 Aug;10(6):369–373.
Published In
Parkinsonism & related disorders
ISSN
1353-8020
Publication Date
August 2004
Volume
10
Issue
6
Start / End Page
369 / 373
Location
england
Related Subject Headings
- Neurology & Neurosurgery
- 1702 Cognitive Sciences
- 1103 Clinical Sciences