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Flavonoids from Andrographis viscosula.

Publication ,  Journal Article
Rao, YK; Damu, AG; Rao, AJ; Venkatesan, S; Kuo, PC; Rao, CV; Wu, TS
Published in: Chemical & pharmaceutical bulletin
December 2003

Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2'-oxygenated flavonoids, (2R)-5-hydroxy-7,2',3'-trimethoxyflavanone (1), 7,2',5'-trimethoxyflavone (2), 5,7,2',3'-tetramethoxyflavone (3), and eight known flavones, 5,7,2'-trimethoxyflavone (4), 5,7,2',4',5'-pentamethoxyflavone (5), echioidinin (6), 5,2',6'-trihydroxy-7-methoxyflavone (7), 5-hydroxy-7,2'-dimethoxyflavone (8), echioidin (9), echioidinin 5-O-glucoside (10), and 5,2',6'-trihydroxy-7-methoxyflavone 2'-O-glucoside (11). The structures of 1-11 were elucidated by physical and spectral methods, including extensive 2D NMR studies. The presence of 2'-oxygenated flavonoids is apparently restricted to Andrographis species in Acanthaceae. Therefore, 2'-oxygenated flavonoids are regarded as chemotaxonomic markers of Andrographis genus in the Acanthaceae family.

Duke Scholars

Published In

Chemical & pharmaceutical bulletin

ISSN

0009-2363

Publication Date

December 2003

Volume

51

Issue

12

Start / End Page

1374 / 1376

Location

japan

Related Subject Headings

  • General Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Rao, Y. K., Damu, A. G., Rao, A. J., Venkatesan, S., Kuo, P. C., Rao, C. V., & Wu, T. S. (2003). Flavonoids from Andrographis viscosula. Chemical & Pharmaceutical Bulletin, 51(12), 1374–1376.
Rao, Y. K., A. G. Damu, A. J. Rao, S. Venkatesan, P. C. Kuo, C. V. Rao, and T. S. Wu. “Flavonoids from Andrographis viscosula.Chemical & Pharmaceutical Bulletin 51, no. 12 (December 2003): 1374–76.
Rao YK, Damu AG, Rao AJ, Venkatesan S, Kuo PC, Rao CV, et al. Flavonoids from Andrographis viscosula. Chemical & pharmaceutical bulletin. 2003 Dec;51(12):1374–6.
Rao, Y. K., et al. “Flavonoids from Andrographis viscosula.Chemical & Pharmaceutical Bulletin, vol. 51, no. 12, Dec. 2003, pp. 1374–76.
Rao YK, Damu AG, Rao AJ, Venkatesan S, Kuo PC, Rao CV, Wu TS. Flavonoids from Andrographis viscosula. Chemical & pharmaceutical bulletin. 2003 Dec;51(12):1374–1376.

Published In

Chemical & pharmaceutical bulletin

ISSN

0009-2363

Publication Date

December 2003

Volume

51

Issue

12

Start / End Page

1374 / 1376

Location

japan

Related Subject Headings

  • General Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry