Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia.

Journal Article (Academic article)

Three new [n-pentyl beta-carboline-1-propionate (1), 5-hydroxymethyl-9-methoxycanthin-6-one (2), and 1-hydroxy-9-methoxycanthin-6-one (3)] and 19 known beta-carboline alkaloids were isolated from the roots of Eurycoma longifolia. The new structures were determined by comprehensive analyses of their 1D and 2D NMR and mass spectral data and by chemical transformation. These compounds were screened for in vitro cytotoxic and antimalarial activities, and 9-methoxycanthin-6-one (4) and canthin-6-one (5) demonstrated significant cytotoxicity against human lung cancer (A-549) and human breast cancer (MCF-7) cell lines.

Duke Authors

Cited Authors

  • Kuo, PC; Shi, LS; Damu, AG; Su, CR; Huang, CH; Ke, CH; Wu, JB; Lin, AJ; Bastow, KF; Lee, KH; Wu, TS

Published Date

  • October 1, 2003

Published In

Volume / Issue

  • 66 / 10

Start / End Page

  • 1324 - 1327

International Standard Serial Number (ISSN)

  • 0163-3864

Conference Location

  • united states