Perioperative management of special populations: immunocompromised host (cancer, HIV, transplantation).


Journal Article (Review)

Optimal perioperative care of the immunocompromised patient requires an understanding of the consequences of disease-specific pharmacologic therapies. The toxicity profile of these therapies can strongly influence the decision algorithms for delivering care in the perioperative period. In this manuscript, the investigators describe the potential effects of drugs commonly used for treatment of patients with cancer, HIV, or transplanted organs, and the impact of these drugs on the care of these patients in the perioperative setting. The article addresses such topics as cardiotoxicity, pulmonary toxicity, hepatotoxicity, genitourinary toxicity, neurotoxicity, myelosuppression, cutaneous toxicity, mitochondrial toxicity, lipodystrophy, hypersensitivity, and liver dysfunction. The article also describes the use of corticosteroids, calcineurin inhibitors, sirolimus, and antimetabolites.

Full Text

Duke Authors

Cited Authors

  • Desai, DM; Kuo, PC

Published Date

  • December 2005

Published In

Volume / Issue

  • 85 / 6

Start / End Page

  • 1267 - xii

PubMed ID

  • 16326207

Pubmed Central ID

  • 16326207

International Standard Serial Number (ISSN)

  • 0039-6109

Digital Object Identifier (DOI)

  • 10.1016/j.suc.2005.09.010


  • eng

Conference Location

  • United States