Immunization against leptospirosis: vaccine trials with heat-killed whole cell and outer envelope antigens in hamsters.


Journal Article (Academic article)

Heat-killed whole cell and outer envelope antigens prepared from homologous virulent and avirulent strains of Leptospira serotypes canicola and pomona were evaluated for protecting hamsters against experimental leptospirosis. The heat-killed bacterins proved at least as effective as the outer envelope antigens, or more so, in providing protection against death and infection, and they are easier and more economical to prepare.

Duke Authors

Cited Authors

  • Zeigler, JA; Jones, RH; Kubica, K

Published Date

  • 1976

Published In

Volume / Issue

  • 10 / 2

Start / End Page

  • 126 - 130

International Standard Serial Number (ISSN)

  • 0085-4638

Conference Location

  • united states