Jaundice: Value of Five-Day Steroid Test in Differential Diagnosis


Journal Article

The clinical efficacy of a short course of steroid therapy in differentiating the etiology of jaundice was determined. Also, observations were made on the mechanism of action of steroids on bilirubin metabolism. A standard five-day course of prednisone, 60 mg daily, was given to 33 patients. The final diagnosis was established by biopsy, laparotomy, or autopsy. Clinically, the response to this course of steroids clearly separated extrahepatic jaundice due to malignancy from intrahepatic jaundice of viral inflammatory origin. In viral hepatitis, the suggested mechanism of action of steroids appears to be enhanced clearing of conjugated bilirubin from the serum. © 1966, American Medical Association. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Wruble, LD; Kalser, MH; Jones, RH; Vloedman, D; Bachorik, P

Published In

Volume / Issue

  • 195 / 3

Start / End Page

  • 184 - 188

Electronic International Standard Serial Number (EISSN)

  • 1538-3598

International Standard Serial Number (ISSN)

  • 0098-7484

Digital Object Identifier (DOI)

  • 10.1001/jama.195.3.184

Citation Source

  • Scopus