Protein metabolism in growth hormone deficiency, and effects of growth hormone replacement therapy.


Journal Article (Academic article)

The effects of growth hormone (GH) treatment on protein metabolism were studied in adults with GH deficiency (GHD). A double-blind, placebo-controlled trial of recombinant human GH, 0.018 IU/kg/day for 1 month followed by 0.036 IU/kg/day for 1 month, was performed with isotopic whole-body protein turnover studies at 0 and 2 months. In all, 18 adults with GHD (9 men, 9 women; mean age, 46.6 years; range, 30-56 years) were studied. Whole-body isotopic leucine turnover using L-[1-13C]leucine was assessed by measuring leucine Ra (a measure of protein degradation), non-oxidative leucine Rd (a measure of protein synthesis) and leucine oxidation rate. Lean body mass and circulating insulin-like growth factor I were significantly (p

Duke Authors

Cited Authors

  • Russell Jones, DL; Weissberger, AJ; Bowes, SB; Kelly, JM; Thomason, M; Umpleby, AM; Jones, RH; Sönksen, PH

Published Date

  • June 1, 1993

Published In

Volume / Issue

  • 128 Suppl 2 /

Start / End Page

  • 44 - 47

International Standard Serial Number (ISSN)

  • 0001-5598

Conference Location

  • denmark