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Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.

Publication ,  Journal Article
Pasipoularides, A; Shu, M; Shah, A; Silvestry, S; Glower, DD
Published in: Am J Physiol Heart Circ Physiol
November 2002

By limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in alert dogs at control (n = 16) and under surgically induced subacute (2-5 wk) RV pressure overload (n = 6), volume overload (n = 7), and ischemia (n = 6) were analyzed. The conventional exponential model detected no changes from control in the passive filling pressure-volume (P(pf)-V) relations. The new sigmoidal model revealed significant quantifiable changes in P(pf)-V relations. Maximum RV MC (MC(max)), attained during early filling, is reduced from control in pressure overload (P = 0.0016), whereas filling pressure at maximum MC (P(MCmax)) is increased (P = 0.0001). End-diastolic RV MC increases significantly in volume overload (P = 0.0131), whereas end-diastolic pressure is unchanged. In ischemia, MC(max) is decreased (P = 0.0102), with no change in P(MCmax). We conclude that the sigmoidal model quantifies important changes in RV diastolic function in alert dog models of pressure overload, volume overload, and ischemia.

Duke Scholars

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

November 2002

Volume

283

Issue

5

Start / End Page

H2140 / H2150

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Function, Right
  • Ventricular Dysfunction, Right
  • Myocardial Ischemia
  • Models, Cardiovascular
  • Heart Failure
  • Dogs
  • Disease Models, Animal
  • Diastole
  • Compliance
 

Citation

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Pasipoularides, A., Shu, M., Shah, A., Silvestry, S., & Glower, D. D. (2002). Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia. Am J Physiol Heart Circ Physiol, 283(5), H2140–H2150. https://doi.org/10.1152/ajpheart.00462.2002
Pasipoularides, Ares, Ming Shu, Ashish Shah, Scott Silvestry, and Donald D. Glower. “Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.Am J Physiol Heart Circ Physiol 283, no. 5 (November 2002): H2140–50. https://doi.org/10.1152/ajpheart.00462.2002.
Pasipoularides A, Shu M, Shah A, Silvestry S, Glower DD. Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H2140–50.
Pasipoularides, Ares, et al. “Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.Am J Physiol Heart Circ Physiol, vol. 283, no. 5, Nov. 2002, pp. H2140–50. Pubmed, doi:10.1152/ajpheart.00462.2002.
Pasipoularides A, Shu M, Shah A, Silvestry S, Glower DD. Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia. Am J Physiol Heart Circ Physiol. 2002 Nov;283(5):H2140–H2150.

Published In

Am J Physiol Heart Circ Physiol

DOI

ISSN

0363-6135

Publication Date

November 2002

Volume

283

Issue

5

Start / End Page

H2140 / H2150

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Function, Right
  • Ventricular Dysfunction, Right
  • Myocardial Ischemia
  • Models, Cardiovascular
  • Heart Failure
  • Dogs
  • Disease Models, Animal
  • Diastole
  • Compliance