Skip to main content
Journal cover image

Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling.

Publication ,  Journal Article
Shah, AS; Atkins, BZ; Hata, JA; Tai, O; Kypson, AP; Lilly, RE; Koch, WJ; Glower, DD
Published in: J Thorac Cardiovasc Surg
August 2000

OBJECTIVE: Right ventricular dysfunction is a poorly understood but persistent clinical problem. This study was undertaken to evaluate ventricular performance and beta-adrenergic receptor signaling in a tricuspid regurgitation model of right ventricular overload. METHODS: Seventeen dogs were chronically instrumented with epicardial dimension transducers. By means of the shell-subtraction model, right ventricular pressure-volume relationships were evaluated in normal and right ventricular overload states. Right ventricular chamber performance was quantified by the stroke work at an end-diastolic volume relationship. RESULTS: Right ventricular volume overload caused a 28% +/- 11% and 31% +/- 9% decline in chamber performance acutely and at 1 week, respectively, whereas end-diastolic volume increased from 45 +/- 21 to 60 +/- 30 mL (P =. 019). beta-Adrenergic receptor signaling in myocardial samples was assessed, examining adenylyl cyclase and G-protein-coupled receptor kinase activity. Stimulated adenylyl cyclase activity significantly decreased, and G-protein-coupled receptor kinase activity significantly increased in both left and right ventricular samples caused by increased levels of beta-adrenergic receptor kinase 1. No change in beta-adrenergic receptor density was seen at 1 week. CONCLUSIONS: Early right ventricular overload is associated with impaired right ventricular chamber contractility, dilation, and, importantly, a biventricular alteration of beta-adrenergic receptor signaling.

Duke Scholars

Published In

J Thorac Cardiovasc Surg

DOI

ISSN

0022-5223

Publication Date

August 2000

Volume

120

Issue

2

Start / End Page

342 / 349

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Dysfunction, Right
  • Tricuspid Valve Insufficiency
  • Stroke Volume
  • Signal Transduction
  • Respiratory System
  • Receptors, Adrenergic, beta
  • Neuropeptide Y
  • Myocardium
  • Linear Models
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shah, A. S., Atkins, B. Z., Hata, J. A., Tai, O., Kypson, A. P., Lilly, R. E., … Glower, D. D. (2000). Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. J Thorac Cardiovasc Surg, 120(2), 342–349. https://doi.org/10.1067/mtc.2000.107278
Shah, A. S., B. Z. Atkins, J. A. Hata, O. Tai, A. P. Kypson, R. E. Lilly, W. J. Koch, and D. D. Glower. “Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling.J Thorac Cardiovasc Surg 120, no. 2 (August 2000): 342–49. https://doi.org/10.1067/mtc.2000.107278.
Shah AS, Atkins BZ, Hata JA, Tai O, Kypson AP, Lilly RE, et al. Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. J Thorac Cardiovasc Surg. 2000 Aug;120(2):342–9.
Shah, A. S., et al. “Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling.J Thorac Cardiovasc Surg, vol. 120, no. 2, Aug. 2000, pp. 342–49. Pubmed, doi:10.1067/mtc.2000.107278.
Shah AS, Atkins BZ, Hata JA, Tai O, Kypson AP, Lilly RE, Koch WJ, Glower DD. Early effects of right ventricular volume overload on ventricular performance and beta-adrenergic signaling. J Thorac Cardiovasc Surg. 2000 Aug;120(2):342–349.
Journal cover image

Published In

J Thorac Cardiovasc Surg

DOI

ISSN

0022-5223

Publication Date

August 2000

Volume

120

Issue

2

Start / End Page

342 / 349

Location

United States

Related Subject Headings

  • Ventricular Pressure
  • Ventricular Dysfunction, Right
  • Tricuspid Valve Insufficiency
  • Stroke Volume
  • Signal Transduction
  • Respiratory System
  • Receptors, Adrenergic, beta
  • Neuropeptide Y
  • Myocardium
  • Linear Models