Means for load variation during echocardiographic assessment of the Frank-Starling relationship.


Journal Article

Because minimally invasive methods of preload variation are not validated for load-insensitive indexes of cardiac performance, intravenous nitroglycerin (NTG), phenylephrine, and saline solution (VOL) boluses were used in blocked and intact autonomic states to alter load and were compared with vena caval occlusion in the assessment of preload recruitable stroke work relationships between stroke work and left ventricular end-diastolic volume in dogs. In both autonomic states NTG and VOL produced comparable linear relationships. NTG and saline solution were combined with noninvasive measurements of left ventricular pressure and volume to construct echocardiographic relationships between stroke work and left ventricular end-diastolic cross-sectional area; NTG produced linear relationships similar to vena caval occlusion. Therefore NTG and VOL reliably alter load in constructing preload recruitable stroke work relationships, and NTG may be used with noninvasive measurements to provide load-insensitive estimates of cardiac function in a minimally invasive manner.

Full Text

Duke Authors

Cited Authors

  • Atkins, BZ; Silvestry, SC; Davis, JW; Kisslo, JA; Glower, DD

Published Date

  • October 1999

Published In

Volume / Issue

  • 12 / 10

Start / End Page

  • 792 - 800

PubMed ID

  • 10511647

Pubmed Central ID

  • 10511647

International Standard Serial Number (ISSN)

  • 0894-7317


  • eng

Conference Location

  • United States