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Assessment of the Frank-Starling relationship by two-dimensional echocardiography.

Publication ,  Journal Article
Zipprich, DA; Owen, CH; Lewis, CW; Gall, SA; Davis, JW; Kisslo, JA; Glower, DD
Published in: J Am Soc Echocardiogr
1996

The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements.

Duke Scholars

Published In

J Am Soc Echocardiogr

DOI

ISSN

0894-7317

Publication Date

1996

Volume

9

Issue

3

Start / End Page

231 / 240

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Systole
  • Stroke Volume
  • Phenylephrine
  • Papillary Muscles
  • Nitroprusside
  • Models, Cardiovascular
  • Image Processing, Computer-Assisted
  • Humans
  • Fourier Analysis
 

Citation

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Zipprich, D. A., Owen, C. H., Lewis, C. W., Gall, S. A., Davis, J. W., Kisslo, J. A., & Glower, D. D. (1996). Assessment of the Frank-Starling relationship by two-dimensional echocardiography. J Am Soc Echocardiogr, 9(3), 231–240. https://doi.org/10.1016/s0894-7317(96)90135-2
Zipprich, D. A., C. H. Owen, C. W. Lewis, S. A. Gall, J. W. Davis, J. A. Kisslo, and D. D. Glower. “Assessment of the Frank-Starling relationship by two-dimensional echocardiography.J Am Soc Echocardiogr 9, no. 3 (1996): 231–40. https://doi.org/10.1016/s0894-7317(96)90135-2.
Zipprich DA, Owen CH, Lewis CW, Gall SA, Davis JW, Kisslo JA, et al. Assessment of the Frank-Starling relationship by two-dimensional echocardiography. J Am Soc Echocardiogr. 1996;9(3):231–40.
Zipprich, D. A., et al. “Assessment of the Frank-Starling relationship by two-dimensional echocardiography.J Am Soc Echocardiogr, vol. 9, no. 3, 1996, pp. 231–40. Pubmed, doi:10.1016/s0894-7317(96)90135-2.
Zipprich DA, Owen CH, Lewis CW, Gall SA, Davis JW, Kisslo JA, Glower DD. Assessment of the Frank-Starling relationship by two-dimensional echocardiography. J Am Soc Echocardiogr. 1996;9(3):231–240.
Journal cover image

Published In

J Am Soc Echocardiogr

DOI

ISSN

0894-7317

Publication Date

1996

Volume

9

Issue

3

Start / End Page

231 / 240

Location

United States

Related Subject Headings

  • Ventricular Function, Left
  • Systole
  • Stroke Volume
  • Phenylephrine
  • Papillary Muscles
  • Nitroprusside
  • Models, Cardiovascular
  • Image Processing, Computer-Assisted
  • Humans
  • Fourier Analysis