Assessment of the Frank-Starling relationship by two-dimensional echocardiography.
The Frank-Starling relationship between left ventricular stroke work and end-diastolic minor-axis cross-sectional area was evaluated as a load-insensitive measure of inotropic state by two-dimensional echocardiography in 10 conscious dogs. Stroke work was calculated as the product of systolic change in cross-sectional area and either (1) beat-to-beat mean arterial pressure or (2) initial systolic blood pressure. Both Frank-Starling relationships were highly linear during preload variation (mean r = 0.96), sensitive to the inotropic state (slope increase with calcium 51% +/- 43% and 62% +/- 53%, respectively), and insensitive to afterload (r < 0.4, slope or x intercept versus afterload). Thus the Frank-Starling relationships derived from two-dimensional echocardiographic images and peripheral arterial pressure may be a useful and practical means of assessing inotropic state with minimally invasive measurements.
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Related Subject Headings
- Ventricular Function, Left
- Systole
- Stroke Volume
- Phenylephrine
- Papillary Muscles
- Nitroprusside
- Models, Cardiovascular
- Image Processing, Computer-Assisted
- Humans
- Fourier Analysis
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Ventricular Function, Left
- Systole
- Stroke Volume
- Phenylephrine
- Papillary Muscles
- Nitroprusside
- Models, Cardiovascular
- Image Processing, Computer-Assisted
- Humans
- Fourier Analysis